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Moumoujus

PERFLUOROHEPTANE.

Avoid CAS 335-57-9 / ABSORBENT, ANTICAKING, EMULSION STABILISING, SKIN CONDITIONING

Perfluoroheptane (C7F16) is a fully fluorinated hydrocarbon, belonging to the broader class of per- and polyfluoroalkyl substances (PFAS). Historically incorporated into cosmetic formulations to condition and smooth the skin, impart shine, and modify product texture, its use is now subject to significant safety and environmental scrutiny.

Summary

Skin conditioning agent Texture enhancer Emulsion stabilizer Anticaking agent Absorbent

Science

Mechanism of Action

This perfluorocarbon is distinguished by its inherently low surface tension, high thermal stability, and exceptional chemical inertness, which renders it resistant to oxidation and degradation. As both hydrophobic and oleophobic, it repels both water and oil. Its function in skincare formulations often involves contributing to a smooth skin feel and influencing the overall consistency and spreadability of the product.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Insoluble in water and oil
Optimal pH N/A
0 7 14

Stability

Perfluoroheptane demonstrates high stability, resistant to oxidation, degradation, acids, and bases under recommended storage conditions. Its water solubility is notably very low, measured at 0.0132 mg/L at 25 °C.

Conflicts

  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Perfluoroheptane is a per- and polyfluoroalkyl substance (PFAS), a class of synthetic chemicals that pose significant health and environmental concerns due to their persistence and bioaccumulation. The broader PFAS class has been linked to potential immunotoxicity, reproductive and developmental toxicity, liver effects, thyroid disruption, and cancer in humans and animals. While specific cosmetic safety data for Perfluoroheptane (C7F16) itself is limited, related compounds like Perfluoroheptane sulfonic acid (PFHpS) have shown skin absorption in murine models, leading to liver damage and immune suppression at concentrations between 0.3125% and 2.5%. The FDA acknowledges PFAS use in cosmetics, and numerous U.S. states (e.g., California, Colorado, Minnesota, Washington) are enacting or proposing bans on intentionally added PFAS in cosmetic products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its classification as a PFAS, Perfluoroheptane presents significant concerns regarding environmental persistence, bioaccumulation, and potential health risks, making it unsuitable for use in precision skincare formulations, especially given ongoing regulatory bans.

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