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PERFLUORODIMETHYLCYCLOHEXANE.

Avoid CAS 335-27-3 / SOLVENT

Perfluorodimethylcyclohexane is an inert, heavy perfluorinated liquid primarily recognized for its ability to act as a carrier for gases like oxygen, potentially offering instantaneous dermal filling and skin renewal benefits. Despite its proposed cosmetic advantages, this ingredient is classified as a Per- and polyfluoralkyl substance (PFAS) and is associated with notable safety concerns and regulatory restrictions.

Summary

Solvent Skin Conditioning Agent Volumizing Agent

Science

Mechanism of Action

This compound, often integrated into 'Fiflow' formulations, functions as a transport agent for gases such as oxygen and argon, delivering them into the skin. This enhanced oxygenation is theorized to contribute to effects including immediate dermal plumping, a temporary muscular relaxation effect, stimulation of skin renewal processes, and improved skin elasticity.

Research

Clinical Evidence

Medium confidence
Effective range 2–15%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data available regarding dusting behavior for this ingredient.

The Formula

Formulation

Solubility
Neither water nor oil, forms a third phase
Optimal pH N/A
0 7 14

Stability

Perfluorodimethylcyclohexane is a stable and inert heavy liquid. Formulations should be prepared at temperatures below 35°C, requiring sufficient viscosity to counteract its high volatility and density, which can lead to separation. It consistently forms a distinct third phase in emulsions. To prevent bubbling due to its gas content, vacuum preparation is advisable, and airless packaging is highly recommended, particularly after oxygen loading.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Perfluorodimethylcyclohexane is categorized as a Per- and polyfluoralkyl substance (PFAS). The EWG Skin Deep database raises significant concerns regarding PFAS, citing potential for enhanced skin absorption, high use restrictions, moderate endocrine disruption, high persistence and bioaccumulation in the environment and body, and moderate non-reproductive organ system toxicity. EWG VERIFIED products strictly prohibit this ingredient. California has noted 'Violation of government restrictions - Banned or found unsafe for use in cosmetics' for this class of compounds. While registered in the FDA Global Substance Registration System (GSRS), this indicates cataloging, not specific approval for cosmetic use. No dedicated CIR safety assessment exists for this specific ingredient, though related polyfluorinated polymers have occasionally lacked sufficient data for full review.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its purported benefits for dermal filling and volumizing, Perfluorodimethylcyclohexane should be avoided due to its classification as a PFAS, significant environmental and health concerns, and known regulatory restrictions in certain regions.

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