Science
Mechanism of Action
Derived synthetically, Pentapeptide-59 mimics a protein from the Heteractis Crispa sea anemone venom (APHC1). Its mechanism involves inhibiting the overactivation of the TRPV1 pain receptor in the skin, thereby inactivating specific dermal pain pathways and reducing discomfort and visible signs of sensitization.
Research
Clinical Evidence
High confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal stability and enhanced bioavailability, Pentapeptide-59 is typically incorporated into a soft sphere carrier system, often based on shea butter, or co-formulated with emollient fatty acids like shea butter or lecithin.
Synergies
- Emollient fatty acids (e.g., shea butter, lecithin)
- Specialized carrier systems (e.g., soft spheres)
Safety
Safety Profile
No specific safety assessments by the Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) have been found for Pentapeptide-59. It is publicly listed on precisionFDA with a UNII (D8G3WTU93Z) and CAS number (1980862-40-5).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pentapeptide-59 is a valuable ingredient for precisely calming reactive skin by directly targeting the TRPV1 pain receptor, offering quantifiable reductions in sensitivity and irritation.
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References
Sources