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PENTAPEPTIDE-24.

Valuable CAS - / SKIN CONDITIONING

PENTAPEPTIDE-24, also known as Palmitoyl Pentapeptide-4 or Matrixyl, is a potent signaling peptide that targets the dermal matrix to stimulate vital collagen production. It works to enhance skin elasticity, reduce the appearance of fine lines and wrinkles, and refine overall skin texture, offering a comprehensive anti-aging benefit.

Summary

Cell-Communicating Collagen Booster Elasticity Enhancer Wrinkle Reducer Skin Firming Texture Refiner

Science

Mechanism of Action

PENTAPEPTIDE-24 functions as a cell-communicating ingredient. Upon penetrating the stratum corneum into the dermis, it acts as a signaling agent by binding to specific cell surface receptors. This action initiates a cascade of cellular pathways, significantly boosting the synthesis of collagen types I and III, which are crucial for skin structure. It also aids in regulating hyaluronic acid production in fibroblasts and can intervene with collagen degradation, leading to higher concentrations of essential fibrillar proteins. This mechanism ultimately improves skin elasticity, results in a smoother and firmer complexion, and visibly diminishes the appearance of fine lines and wrinkles.

Research

Clinical Evidence

High confidence
Effective range 0.0003–1.2%
Optimal

0.0003%

Key findings

  1. 01 At 0.0003%, PENTAPEPTIDE-24 significantly reduces fine lines and wrinkles and improves skin texture, demonstrating wrinkle-reducing efficacy comparable to 0.07% retinol while offering superior skin tolerability.
  2. 02 A 0.005% concentration applied twice daily for 28 days resulted in an 18% decrease in fold depth, a 37% decrease in fold thickness, and a 21% increase in skin firmness.
  3. 03 Commercial anti-aging formulations have effectively utilized PENTAPEPTIDE-24 in concentrations ranging from 0.80% to 1.20% to enhance skin hydration and combat signs of aging.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.0003%
Red flag below
0.0002%

PENTAPEPTIDE-24 demonstrates significant clinical efficacy at remarkably low concentrations. Therefore, any product claiming its benefits should contain at least 0.0003% to be considered clinically relevant and avoid the perception of 'dusting,' where an ingredient is included below its effective threshold.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The KTTKS amino sequence of this peptide is attached to palmitic acid, enhancing its oil solubility and improving skin penetration. Products formulated with PENTAPEPTIDE-24 are designed for shelf stability.

Safety

Safety Profile

CIR Status
Under review
Max tested
3%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel is currently reviewing related pentapeptides. Despite this, PENTAPEPTIDE-24 is widely regarded as ultra-gentle, with a 3% concentration shown to be safe, non-irritating, and non-sensitizing, indicating suitability for various skin types without adverse effects on the skin barrier.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

PENTAPEPTIDE-24 is a valuable anti-aging peptide proven to significantly reduce wrinkles and improve skin firmness and texture, even at very low concentrations, with excellent tolerability across all skin types.

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