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Moumoujus

PENTAPEPTIDE-23.

Insufficient Data CAS - / SKIN CONDITIONING

PENTAPEPTIDE-23 is a synthetic signal peptide, part of a class of compounds recognized for their capacity to mimic natural skin communication signals. While its exact biological actions are not yet fully elucidated, similar pentapeptides are known to contribute to maintaining extracellular matrix health.

Summary

Signaling Peptide Potential Collagen Stimulation Potential Elastin Enhancement Potential Anti-Inflammatory Potential MMP Inhibition

Science

Mechanism of Action

While the precise mechanism of action for PENTAPEPTIDE-23 on the skin is not extensively detailed in available literature, pentapeptides generally function as biomimetic signaling molecules. They are thought to communicate with dermal cells to initiate repair and rejuvenation processes. For instance, well-characterized pentapeptides such as Palmitoyl Pentapeptide are known to stimulate the biosynthesis of key extracellular matrix proteins, including various types of collagen (especially types I, III, and IV), elastin, fibronectin, and hyaluronic acid, leading to enhanced skin elasticity and firmness. Other related pentapeptides, like Acetyl Pentapeptide-1, operate by influencing cellular communication, suppressing pro-inflammatory cytokines such as Interleukin-8 (IL-8), and inhibiting matrix metalloproteinases (MMPs), particularly MMP-9, thereby contributing to the preservation of collagen and elastin integrity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for PENTAPEPTIDE-23 stability is not available. However, peptide stability is generally pH-dependent; for example, some peptides demonstrate relative stability at low pH values (e.g., pH 4.5). Peptides containing free cysteine residues require reconstitution in carefully degassed acidic buffers, as these thiol moieties can rapidly oxidize at pH levels above 7. Many peptides can also be solubilized in PBS at pH 7.0–7.4, typically at concentrations up to 1 mg/mL.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

PENTAPEPTIDE-23 has not been individually reviewed for safety by the Cosmetic Ingredient Review (CIR) Expert Panel. Nevertheless, related pentapeptides, including Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and Pentapeptide-4 (known for its Lysine-Threonine-Threonine-Lysine-Serine sequence), have been assessed by the CIR Expert Panel and deemed safe for cosmetic use within current industry practices and concentrations. These related ingredients are not subject to restrictions under European Union cosmetic regulations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While the broader class of pentapeptides demonstrates promising benefits for skin rejuvenation, there is currently insufficient specific data regarding the efficacy and safety of PENTAPEPTIDE-23 to ascertain its definitive role.

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