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PENTAMETHYLCYCLOPENT-3-ENE-BUTANOL.

Questionable CAS 65113-99-7 / PERFUMING

PENTAMETHYLCYCLOPENT-3-ENE-BUTANOL, also known as Sandalore, is a synthetic sandalwood aroma compound primarily used as a fragrance. It has demonstrated potential in promoting hair growth, skin-cell proliferation, and wound healing.

Fragrance Hair Conditioning Perfuming Skin-cell proliferation Wound healing

Science

This compound acts as an agonist for the olfactory receptor OR2AT4, found in human keratinocytes. Its stimulation in hair follicles decreases apoptosis and increases IGF-1, enhancing hair growth, and it also supports skin-cell proliferation.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Enhances hair growth by stimulating olfactory receptor OR2AT4, decreasing apoptosis and increasing IGF-1 in hair follicles.
  2. 02 Promotes skin-cell proliferation and wound healing.

Transparency

Not commonly dusted

While commonly used as a fragrance at low concentrations (0.2-1%), the specific optimal concentrations for its stated therapeutic benefits (hair growth, wound healing) are not clearly established, preventing it from being considered frequently dusted for those purposes.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

It is a flammable liquid; handle with care and keep away from heat and ignition sources. Store in tightly closed containers with grounded equipment.

Conflicts

  • Oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
8.1%
Sensitization risk High

This ingredient is not CIR reviewed. IFRA restricts its use due to dermal sensitization, with maximum concentrations varying significantly by product category. It causes serious eye damage and skin irritation, with moderate concerns for allergies and organ toxicity.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Questionable

Despite potential benefits for hair growth and skin healing, its high irritancy, significant sensitization risk, and flammability warnings make it highly questionable for general cosmetic applications.


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