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PENTAMETHYL-CYCLOPENT-1-ENYL METHYL KETONE.

Questionable CAS 13144-88-2 / PERFUMING

Pentamethyl-Cyclopent-1-Enyl Methyl Ketone is a synthetic aroma compound primarily incorporated into skincare and cosmetic formulations for its distinct fragrance. While it enhances product scent, it offers no direct dermatological benefits and is recognized as a potential skin sensitizer, necessitating precise formulation within strict regulatory limits.

fragrance

Science

This ingredient functions exclusively as a fragrance agent, imparting scent to products. No specific mechanism of action related to direct skin benefits or physiological effects on the skin has been elucidated.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted
Red flag below
0.023%

This ingredient is considered a skin sensitizer, with specific restriction limits defined by IFRA for various product categories. Exceeding these limits, which can be as low as 0.023% in products for axillae, significantly elevates the risk of dermal sensitization and allergic reactions. The No Expected Sensitization Induction Level (NESIL) is established at 1500 μg/cm2. Therefore, while not commonly 'dusted' in the sense of general overuse, any application beyond established safe concentrations constitutes a notable safety concern, particularly in leave-on products or those with prolonged skin contact.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for the stability of Pentamethyl-Cyclopent-1-Enyl Methyl Ketone have not been identified in the provided research. It is generally formulated within the pH parameters compatible with the overall product.


Safety

CIR Status
Safe with restrictions
Sensitization risk Moderate

Classified as safe with restrictions by the Cosmetic Ingredient Review (CIR) Expert Panel, this ingredient is a known skin sensitizer. The International Fragrance Association (IFRA) mandates strict maximum concentration limits in finished products to mitigate dermal sensitization risk, ranging from 0.023% for products applied to the axillae to 3% for certain household care items. GHS classification indicates it 'May cause an allergic skin reaction'.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Questionable

As a pure fragrance ingredient offering no skin benefits and carrying a documented risk of sensitization, its inclusion in precision skincare formulations is questionable, particularly for sensitive or reactive skin.


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