Science
Mechanism of Action
This ingredient operates by forming a fine, moisture-absorbing film on the skin's surface. This film creates a perceptible tightening sensation through physical contraction. The base polymer, pullulan, intrinsically functions as a thickener; the acetylation to PEI-42 Pullulan Acetate enhances its hydrophobicity, a property utilized in advanced drug delivery systems via nanoparticle formation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The foundational pullulan polymer exhibits robust stability across a wide pH range, specifically between 2 and 11. Pullulan acetate, particularly with a degree of substitution (DS) of 3.0, demonstrates an affinity for organic solvents, forming semi-clear gels in solutions such as dimethyl sulfoxide (DMSO).
Safety
Safety Profile
The base polymer, pullulan, is generally considered safe, exhibiting non-toxic, non-mutagenic, non-carcinogenic, non-immunogenic, biocompatible, and biodegradable properties. It holds GRAS (Generally Recognized as Safe) status by the FDA. However, specific safety assessments by the CIR or SCCS for the acetate derivative, PEI-42 Pullulan Acetate, are not available. Animal studies involving pullulan acetate as a drug nanocarrier indicated it was well tolerated at a dosage of 200 mg/kg in mice.
Your Skin
Skin Compatibility
Our Assessment
Verdict
PEI-42 Pullulan Acetate is a valuable ingredient for its dual benefits as a film former providing an instant tightening effect and as a cosmetic thickener, with its base polymer having a strong safety profile.
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References
Sources