Science
Mechanism of Action
As a highly charged cationic polymer, PEI-1400 functions by establishing robust ionic interactions with negatively charged molecules, particles, and surfaces within a formulation. This high charge density enables it to effectively bind, thereby modulating viscosity, forming cohesive films, and imparting conditioning benefits. While Polyethylenimine has complex biochemical mechanisms in other fields, such as gene therapy, these are not considered directly relevant to its established actions on the skin in cosmetic applications.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
PEI-1400 is soluble in hot water and at low pH (typically <2.0 for initial dissolution). Stock solutions can be stable for up to one year at -20 °C or three months at 2-8 °C, particularly when adjusted to a physiological pH range of 6.9-7.1. The polymer exhibits natural pH buffering capacity.
Conflicts
- acids
- anionic compounds
- strong oxidizing agents
Safety
Safety Profile
PEI-1400 (Polyethylenimine) has not undergone specific review by the Cosmetic Ingredient Review (CIR) or SCCS for cosmetic use. While certain molecular weights of Polyethylenimine have received FDA approval for specific biomedical uses and as inert pesticide ingredients (with low skin absorption noted for ~1,300 daltons), general safety data sheets indicate potential hazards, including serious eye damage and irritation to skin and respiratory systems. Reports from some cosmetic databases suggest PEI-1400 may induce irritation, inflammation, or dryness. Furthermore, Polyethylenimine can exhibit cellular toxicity at elevated concentrations through membrane disruption, leading to cell death. This ingredient is also not readily biodegradable.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its functional benefits in viscosity control and film formation, PEI-1400 is of questionable value in precision skincare due to a lack of specific cosmetic safety assessments, documented irritation potential, and concerns regarding cellular toxicity and biodegradability.
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