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PEG/PPG-3/6 DIMETHYL ETHER.

Valuable CAS 61419-46-3 / SKIN CONDITIONING

PEG/PPG-3/6 Dimethyl Ether is a sophisticated polyoxyethylene/polyoxypropylene derivative engineered to enhance skin hydration and fortify the skin's natural barrier. It delivers significant moisture retention without a sticky feel, visibly improving dry skin with consistent application.

Summary

Skin conditioning Humectant Solvent Emulsifier Surfactant

Science

Mechanism of Action

This ingredient, also known as EPDME, improves skin barrier function by increasing the structural order of lipid layers within the stratum corneum, observed to a depth of approximately 3 µm from the surface. This enhancement is evidenced by an elevated GP value and reduced Lucifer yellow diffusion into the epidermis. Additionally, it functions as a skin conditioning agent, humectant, emulsifier, surfactant, and solvent.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Daily application effectively prevents and improves dry skin by providing high, non-sticky moisture retention.
  2. 02 Demonstrates a synergistic hydrating effect when combined with glycerol for dry skin.
  3. 03 Strengthens the skin barrier by enhancing lipid ordering in the stratum corneum and reducing epidermal permeability.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Exhibits good stability across acidic and alkaline pH ranges.

Synergies

  • Glycerol (enhances hydrating effect for dry skin)

Conflicts

  • Strong acids
  • Strong bases
  • Strong oxidizers

Safety

Safety Profile

CIR Status
Safe as used
Max tested
7%
Sensitization risk Low

The CIR Expert Panel concluded that 131 alkyl PEG/PPG ethers, including PEG/PPG-3/6 Dimethyl Ether, are safe in cosmetic practices when formulated to be non-irritating. A maximum reported leave-on use concentration for a similar ingredient, PEG/PPG-14/7 dimethyl ether, is up to 7% in face, neck, body, and hand products.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PEG/PPG-3/6 Dimethyl Ether is a valuable ingredient for its dual benefits of superior, non-sticky moisture retention and proven skin barrier enhancement, making it particularly beneficial for dry and normal skin types.

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