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PEG-9 TRIMETHYLOLPROPANE TRIACRYLATE.

Avoid CAS 28961-43-5 / SKIN CONDITIONING

PEG-9 TRIMETHYLOLPROPANE TRIACRYLATE is a polyethylene glycol derivative primarily used as a skin conditioning agent. While it can maintain skin in good condition, extensive research indicates a high potential for skin irritation and sensitization.

Summary

skin conditioning film-forming solubilizer solvent

Science

Mechanism of Action

This ingredient functions by helping to maintain the skin in a healthy condition. As a polyethylene glycol derivative, it may also contribute to the formation of a continuous film on skin, hair, or nails. Additionally, it could serve as a solubilizer or solvent for other cosmetic components.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In BALB/c mice, concentrations exceeding 0.25% were found to induce skin irritation.
  2. 02 A 10% solution applied dermally to mice in acetone caused severe skin burning, crusting, and hair loss.
  3. 03 A 5% solution applied dermally in mineral oil showed only very slight crusting in mice after 5 weeks, suggesting the vehicle may mitigate irritation.
  4. 04 In guinea pigs, a 0.5% concentration in acetone:olive oil elicited mild to moderate skin sensitization.
  5. 05 Human patch tests involving UV-cured printing inks containing this ingredient at 0.2% (in petrolatum) resulted in positive reactions categorized as irritant, not allergic.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The core component, trimethylolpropane triacrylate, is susceptible to spontaneous polymerization when exposed to direct sunlight and heat. It is incompatible with strong oxidizing agents, acids, and bases, but can be stabilized effectively with hydroquinone monomethyl ether.

Conflicts

  • strong oxidizing agents
  • acids
  • bases
  • direct sunlight
  • heat

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically assessed PEG-9 TRIMETHYLOLPROPANE TRIACRYLATE. While related PEG derivatives have been deemed safe in cosmetics when non-irritating, this ingredient presents distinct concerns. Comprehensive studies indicate significant irritation potential at concentrations as low as 0.2% in humans and over 0.25% in mice, alongside a notable risk for skin sensitization in animal models.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the consistent evidence of high irritation and sensitization potential across multiple studies, even at low concentrations, this ingredient poses a significant risk and should be avoided in precision skincare formulations.

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