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PEG-6 TRIMETHYLOLPROPANE TRIACRYLATE.

Avoid CAS 28961-43-5 / BINDING, FILM FORMING

PEG-6 TRIMETHYLOLPROPANE TRIACRYLATE is a trifunctional acrylate ester monomer predominantly found in industrial applications like UV-curable coatings and specialized adhesives. Chemically similar to trimethylolpropane triacrylate (TMPTA), it is engineered for free radical polymerization, leading to the formation of highly cross-linked polymers.

Summary

Binding Film Forming

Science

Mechanism of Action

As a trifunctional acrylate ester monomer, PEG-6 TRIMETHYLOLPROPANE TRIACRYLATE is designed to undergo free radical polymerization, typically initiated by ultraviolet light or peroxy compounds, resulting in the creation of cross-linked polymers. When applied to skin, its chemically similar analogue, trimethylolpropane triacrylate (TMPTA), has been shown to be absorbed and induce sustained epidermal cell proliferation, dose-dependent hyperplastic and necrotizing lesions of the epidermis, sebaceous gland hyperplasia, and chronic dermal inflammation in rat and mouse models.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Identified as an irritant in BALB/c mice.
  2. 02 Elicited positive skin sensitization reactions in guinea pigs.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient's primary utility is in industrial polymerization processes, not as an active component in cosmetic formulations. Therefore, the concept of 'dusting' related to exceeding an effective concentration for beneficial skin outcomes is not applicable.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This compound is hygroscopic and sensitive to light, prone to spontaneous polymerization when exposed to direct sunlight and heat. Stability can be enhanced with the addition of monomethyl ester of hydroquinone, and it generally maintains chemical stability under standard room temperature conditions.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong bases
  • Direct sunlight and heat (induces polymerization)
  • Brass
  • Copper
  • Steel (all types and surface treatments)
  • Iron and iron salts

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Specific safety evaluations for PEG-6 TRIMETHYLOLPROPANE TRIACRYLATE are limited. However, extensive data on its chemically similar analogue, Trimethylolpropane Triacrylate (TMPTA), indicates significant safety concerns. TMPTA is categorized as a Skin Corrosion/Irritation Category 2, Serious Eye Damage/Eye Irritation Category 2, and Skin Sensitization Category 1, signifying its potential to cause skin irritation and allergic skin reactions. It is also suspected of causing cancer (H351), classified as a Group 2B carcinogen (possibly carcinogenic to humans) by IARC, and listed by California Proposition 65 as a known carcinogen. Animal studies have observed significantly increased incidences of papillomas and squamous cell carcinomas of the skin at dermal application sites.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its documented high risk of irritation, sensitization, and classification as a suspected carcinogen in animal studies, PEG-6 TRIMETHYLOLPROPANE TRIACRYLATE is not suitable for precision skincare formulations and should be avoided.

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