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PEG-6 DIISOSTEARATE.

Insufficient Data / SURFACTANT - EMULSIFYING

PEG-6 DIISOSTEARATE is a synthetic polyethylene glycol derivative functioning primarily as a surfactant and emulsifying agent, critical for the stable blending of oil and water components in skincare formulations. Its unique molecular structure facilitates the creation of stable emulsions.

Summary

Emulsifying Surfactant Solubilizing Humectant Penetration Enhancer

Science

Mechanism of Action

This ingredient operates by significantly lowering the interfacial tension between typically immiscible oil and water phases, allowing for their stable incorporation into an emulsion. Its amphiphilic structure, comprising both hydrophilic polyethylene glycol segments and lipophilic diisostearate groups, enables it to effectively bridge and stabilize these distinct components. Furthermore, PEGs, including this derivative, can function as solubilizers, humectants, and enhancers for the skin penetration of other active ingredients.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Polyethylene glycols can undergo oxidative degradation, leading to peroxide formation, if exposed to temperatures exceeding 50°C for extended periods. The inclusion of antioxidants in the final product can help mitigate these radical mechanisms.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Panel has determined that there is insufficient data to conclude the safety of PEG-6 DIISOSTEARATE under its intended conditions of use in cosmetic formulations. This ingredient belongs to a group of fatty ester end-capped alkoxylates where safety data for 13 out of 14 components, including PEG-6 DIISOSTEARATE, was lacking, contrasting with PEG/PPG-8/3 Diisostearate which was deemed safe. While PEGs are generally tolerated on normal skin and are not typically sensitizing, concerns exist regarding potential impurities such as 1,4-dioxane and ethylene oxide, which manufacturers are advised to minimize. It should not be applied to damaged or compromised skin, such as in burn patients, as it can be readily absorbed, potentially leading to contact dermatitis and systemic toxicity. Some individuals with sensitive skin may also experience irritation or allergic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

PEG-6 DIISOSTEARATE is a valuable emulsifier for creating stable product formulations, though its formal safety assessment by the CIR Panel currently indicates insufficient data for a conclusive determination.

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