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PEG-5 HYDROGENATED LANOLIN.

Valuable CAS 68648-27-1 / SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMULSIFYING

A hydrophilized derivative of natural lanolin, PEG-5 Hydrogenated Lanolin serves as a dual-action ingredient, providing significant skin conditioning benefits and essential emulsifying properties. It effectively enhances skin hydration and barrier function while stabilizing cosmetic formulations.

Summary

skin conditioning - emollient surfactant - emulsifying

Science

Mechanism of Action

PEG-5 Hydrogenated Lanolin functions primarily as an emollient and a surfactant. As an emollient, it establishes a lubricating layer on the skin's surface, enriching it with exogenous lipids to impart a visibly soft and smooth appearance. This action is crucial for fortifying the skin's natural barrier, subsequently improving hydration levels and mitigating transepidermal water loss. Concurrently, its role as a surfactant enables it to reduce interfacial tension between dissimilar phases, facilitating the formation and maintenance of stable emulsions in diverse product matrices.

Research

Clinical Evidence

High confidence
Effective range 10–100%
Optimal

N/A

Key findings

  1. 01 In human patch tests, concentrations up to 60% were consistently reported as non-irritating and non-sensitizing, demonstrating excellent dermal tolerance.
  2. 02 Animal studies conducted with concentrations ranging from 10% to 100% indicated mild or negligible skin irritation and confirmed a nonsensitizing profile.
  3. 03 Ocular irritation assessments in rabbits, utilizing concentrations of 50% to 100%, revealed minimal to no eye irritation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 2 – 10
0 7 14

Stability

PEG-5 Hydrogenated Lanolin exhibits robust stability across a broad pH spectrum, ranging from 2 to 10. It demonstrates general compatibility with most nonionic solubilizers and maintains stability in electrolyte solutions up to 10%. While moderately resistant to oxidative and reducing agents, prolonged heating above 80 °C should be avoided to preserve its integrity.

Synergies

  • Nonionic solubilizers
  • Electrolyte solutions (up to 10%)

Conflicts

  • Prolonged heating above 80 °C

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that PEG-5 Hydrogenated Lanolin is safe as utilized in cosmetic and personal care products. Although ethoxylation processes may introduce trace amounts of 1,4-dioxane, stringent purification methods effectively control its presence, and regulatory bodies like the FDA actively monitor levels. Comprehensive toxicological evaluations, including acute oral, dermal, and inhalation studies, have shown no evidence of toxicity, mutagenicity, carcinogenicity, or developmental toxicity for its constituent components. Its listing in the EU cosmetic ingredient database (CosIng) further affirms its regulatory compliance within the European Union.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PEG-5 Hydrogenated Lanolin is a valuable multifunctional ingredient, delivering effective skin conditioning and critical formulation stability with a strong safety profile and broad compatibility across most skin types.

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