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Moumoujus

PEG-200.

Valuable CAS 25322-68-3 / HUMECTANT, SOLVENT

PEG-200 is a versatile polyethylene glycol compound primarily functioning as a humectant to draw moisture into the skin. It also serves as an effective solvent and solubilizer, improving the dispersion of other ingredients and enhancing product stability and texture.

Summary

Humectant Solvent Solubilizer Viscosity-modifying agent Emulsifier Binder Thickener Emollient Lubricant Penetration enhancer Keratolytic (mild)

Science

Mechanism of Action

PEG-200 acts as a potent humectant, efficiently attracting and retaining water molecules to maintain optimal skin hydration and prevent moisture loss. Its capabilities extend to functioning as a versatile solvent and solubilizer, ensuring an even distribution of other cosmetic ingredients throughout a formulation and bolstering overall product stability. Furthermore, it modifies viscosity, influencing the texture and spreadability of formulations. PEG-200 can also serve as an emulsifier, binder, emollient, lubricant, and notably, a penetration enhancer, thereby facilitating the dermal delivery of active ingredients.

Research

Clinical Evidence

High confidence
Effective range 10–30%
Optimal

N/A

Key findings

  1. 01 Incorporating 10% PEG-200 into oleaginous and emulsion bases has demonstrated enhanced release rates for antibiotics like rosoxacin and oxolinic acid, optimizing their therapeutic effects within topical applications.
  2. 02 Formulations containing 20-30% PEG-200 have shown mild keratolytic effectiveness and the ability to maintain skin hydration without irritation, making them beneficial components in treatments for conditions such as ichthyosis.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding 'dusting' or over-formulation thresholds for PEG-200 was found in the provided research.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

PEG-200 is characterized by low volatility and high thermal stability, remaining stable and nonreactive under normal conditions. To maintain its integrity, it should be stored away from open flames, direct sunlight, and strong oxidizing agents. Regular monitoring for pH shifts, the presence of acids, or a significant decrease in glycol concentration can indicate potential degradation.

Synergies

  • Enhances penetration and bioavailability of other active ingredients.
  • Improves solubilization and dispersion of poorly soluble compounds.

Conflicts

  • strong oxidizing agents
  • strong acids

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The CIR Expert Panel has concluded that PEG ingredients, including PEG-200, are safe for use in cosmetic products. They exhibit low oral and dermal toxicity, with minimal absorption through intact skin. While generally considered minimally irritating and non-sensitizing, lower molecular weight PEGs (200-700) have been associated with isolated cases of contact dermatitis, urticaria, and anaphylaxis, particularly at higher concentrations or when applied to compromised skin. Notably, kidney toxicity was reported in severely burned patients treated with PEG-based antimicrobial creams due to significantly increased penetration. Small amounts of 1,4-dioxane, a by-product of ethoxylation, may be present but are controlled through purification. The FDA permits PEG for various uses, including as a cosmetic vehicle or base.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

PEG-200 is a valuable, multifunctional ingredient that enhances skin hydration, improves formulation aesthetics and stability, and facilitates the delivery of active compounds, with a robust safety profile for intact skin.

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