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Moumoujus

PARACHLORELLA BEIJERINCKII EXTRACT.

Valuable / HUMECTANT

Parachlorella Beijerinckii Extract is a microalgae-derived ingredient recognized for its robust anti-aging capabilities, primarily by addressing advanced glycation and reducing inflammation. It also functions as a powerful antioxidant, safeguarding the skin from environmental stressors and supporting overall skin health.

Summary

anti-aging anti-inflammatory antioxidant humectant promotes skin elasticity supports cell regeneration skin-tone evening skin-identical ingredient

Science

Mechanism of Action

This extract primarily acts by significantly inhibiting the formation and accumulation of Advanced Glycation End products (AGEs), which are known contributors to visible skin aging. Simultaneously, it suppresses Receptor for AGEs (RAGE)-mediated inflammation, further protecting the skin's integrity. Additional benefits include potent antioxidant protection against free radicals and pollutants, promotion of skin elasticity, support for cell regeneration, and contribution to skin hydration.

Research

Clinical Evidence

Medium confidence
Effective range 1.65 μg/mL (containing 1 μM lutein)–16.5 μg/mL (containing 10 μM lutein)%
Optimal

N/A

Key findings

  1. 01 In an in vitro skin dermis-like model, this concentration of fat-soluble Parachlorella beijerinckii extract effectively suppressed the formation of fluorescent Advanced Glycation End products (AGEs), including Nε-(carboxymethyl) lysine (CML) and Nε-(carboxymethyl) arginine (CMA). It also attenuated glyoxal-induced gel contraction and inhibited the increase of interleukin-8 (IL-8) and Receptor for AGEs (RAGE) protein expression, demonstrating significant antiglycation and anti-inflammatory effects relevant to skin aging.
  2. 02 In the same in vitro study, a higher concentration of the fat-soluble extract demonstrated similar, and in some cases more pronounced, inhibitory effects on AGEs formation, attenuation of glyoxal-induced gel contraction, and reduction of RAGE-mediated inflammation, further supporting its potential for anti-aging and anti-inflammatory applications.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The active antiglycation components, such as carotenoids, are primarily fat-soluble. Related Chlorella extracts (e.g., chlorophylls) have shown sensitivity to acidic pH, potentially leading to degradation (pheophytinization) and color changes, while demonstrating greater stability under alkaline conditions (e.g., pH 7.5). General formulation practices should prioritize protection against oxidation for ingredients rich in carotenoids and vitamins.

Conflicts

  • Acidic pH (potential for degradation and color change)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Parachlorella beijerinckii has a long history of use as a health food supplement and is generally considered safe for consumption. However, a specific safety assessment by the Cosmetic Ingredient Review (CIR), SCCS, or FDA for its use as a cosmetic ingredient was not identified in the available data.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Parachlorella Beijerinckii Extract is a valuable ingredient, demonstrating significant in vitro potential for combating glycation and inflammation, crucial factors in skin aging, while also offering antioxidant and hydrating benefits.

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