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PANTOEA VAGANS/ERYNGIUM MARITIMUM CALLUS FERMENT EXTRACT FILTRATE.

Valuable / HUMECTANT, SKIN CONDITIONING

This innovative ingredient is a precision-fermented extract derived from Sea Holly (Eryngium maritimum) callus culture. Utilizing Pantoea vagans for fermentation, it functions as a multi-beneficial skin conditioning agent and humectant, delivering advanced hydration, barrier support, and anti-aging effects.

Humectant Skin Conditioning Antioxidant Anti-inflammatory Skin Barrier Support Anti-aging Hydration Collagen Boosting Soothing

Science

The ferment extract operates through several key pathways: it significantly boosts the expression of filaggrin (FLG) for enhanced skin barrier function, and increases aquaporin 3 (AQP3) and telomerase reverse transcriptase (TERT) gene expression, promoting hydration and anti-aging. It simultaneously reduces inflammation by decreasing cyclooxygenase-2 (COX2) expression. As an antioxidant, it neutralizes free radicals and supports collagen synthesis, protecting skin from environmental stressors. When formulated as plant exosomes, it activates human skin cells to further reduce inflammation, improve barrier resilience, and soothe redness.


Research

Medium confidence
Effective range 0.01–5%
Optimal

1%

Key findings

  1. 01 In vitro studies utilizing 1% Eryngium maritimum L. callus extract filtrate (ECMF) demonstrated a significant increase in genes vital for skin barrier function (FLG), a reduction in inflammatory markers (COX2), and evidence of anti-aging (TERT) and hydration (AQP3) benefits.
  2. 02 Clinical trials involving 'Cellbiome', an ECMF encapsulated in multilayered liposomes, showed marked improvements in skin hydration, density, and elasticity, alongside a reduction in visible wrinkles.
  3. 03 Recommended application concentrations for related Eryngium maritimum callus filtrates, such as 'BotaniCellar™' and 'BotaniExo™', range from 0.01% to 5% for their comprehensive repairing, soothing, antioxidant, and moisturizing properties.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This ingredient is highly adaptable, available as a water-soluble liquid or lyophilized powder, integrating seamlessly into diverse formulations such as serums, creams, and masks. Liposome-encapsulated forms (e.g., 'Cellbiome', 'BotaniExo™') are noted for enhanced stability and superior absorption, facilitating efficient delivery of bioactive compounds into deeper skin layers.


Safety

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated PANTOEA VAGANS/ERYNGIUM MARITIMUM CALLUS FERMENT EXTRACT FILTRATE. While broader categories of fermented ingredients sometimes lack comprehensive safety data, a related ingredient, 'Eryngium Maritimum Extract', is classified by SkinSAFE as 'Irritant Free' and safe for various sensitive applications (Teen, Lip, Baby, Eyelid), suggesting a generally favorable profile for the plant derivative itself.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

This fermented marine plant extract offers a comprehensive range of benefits, including significant hydration, barrier support, anti-aging, and anti-inflammatory properties, making it a valuable active for diverse skin concerns and types.


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