Science
Mechanism of Action
The ferment extract operates through several key pathways: it significantly boosts the expression of filaggrin (FLG) for enhanced skin barrier function, and increases aquaporin 3 (AQP3) and telomerase reverse transcriptase (TERT) gene expression, promoting hydration and anti-aging. It simultaneously reduces inflammation by decreasing cyclooxygenase-2 (COX2) expression. As an antioxidant, it neutralizes free radicals and supports collagen synthesis, protecting skin from environmental stressors. When formulated as plant exosomes, it activates human skin cells to further reduce inflammation, improve barrier resilience, and soothe redness.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 In vitro studies utilizing 1% Eryngium maritimum L. callus extract filtrate (ECMF) demonstrated a significant increase in genes vital for skin barrier function (FLG), a reduction in inflammatory markers (COX2), and evidence of anti-aging (TERT) and hydration (AQP3) benefits.
- 02 Clinical trials involving 'Cellbiome', an ECMF encapsulated in multilayered liposomes, showed marked improvements in skin hydration, density, and elasticity, alongside a reduction in visible wrinkles.
- 03 Recommended application concentrations for related Eryngium maritimum callus filtrates, such as 'BotaniCellar™' and 'BotaniExo™', range from 0.01% to 5% for their comprehensive repairing, soothing, antioxidant, and moisturizing properties.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is highly adaptable, available as a water-soluble liquid or lyophilized powder, integrating seamlessly into diverse formulations such as serums, creams, and masks. Liposome-encapsulated forms (e.g., 'Cellbiome', 'BotaniExo™') are noted for enhanced stability and superior absorption, facilitating efficient delivery of bioactive compounds into deeper skin layers.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated PANTOEA VAGANS/ERYNGIUM MARITIMUM CALLUS FERMENT EXTRACT FILTRATE. While broader categories of fermented ingredients sometimes lack comprehensive safety data, a related ingredient, 'Eryngium Maritimum Extract', is classified by SkinSAFE as 'Irritant Free' and safe for various sensitive applications (Teen, Lip, Baby, Eyelid), suggesting a generally favorable profile for the plant derivative itself.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This fermented marine plant extract offers a comprehensive range of benefits, including significant hydration, barrier support, anti-aging, and anti-inflammatory properties, making it a valuable active for diverse skin concerns and types.
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