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Moumoujus

PANTOEA AGGLOMERANS/WHEAT FLOUR FERMENT EXTRACT.

Valuable / SKIN CONDITIONING

A fermented botanical extract, PANTOEA AGGLOMERANS/WHEAT FLOUR FERMENT EXTRACT harnesses the immune-modulating power of lipopolysaccharide (IP-PA1) to support skin health. It is engineered to promote innate immunity, accelerate tissue repair, and provide significant anti-inflammatory benefits, making it particularly effective for compromised or sensitive skin conditions.

Summary

Anti-inflammatory Immune-modulating Skin Regeneration Wound Healing Barrier Support Reduces Atopic Dermatitis Symptoms

Science

Mechanism of Action

The core active component, IP-PA1 (lipopolysaccharide derived from Pantoea agglomerans), exerts its effects by activating macrophages, critical components of the innate immune system, thereby contributing to cellular homeostasis. On the skin, IP-PA1 directly stimulates the migration of human keratinocytes through TLR4 signaling, indicating its capacity to enhance tissue regeneration and wound healing. Furthermore, it demonstrates potent anti-inflammatory properties, mitigating epidermal and dermal hyperplasia and reducing inflammatory cell infiltration.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.1%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Current research does not indicate that this ingredient is commonly 'dusted' at ineffective concentrations. Clinical efficacy data is derived from an oral murine study.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While the Pantoea agglomerans organism itself is sensitive to heat, the stability of the processed extract's active components, particularly IP-PA1, under thermal processing requires specific evaluation to ensure efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
4500%
Sensitization risk Low

The fermented flour extract, rich in IP-PA1, has been confirmed as very safe for both oral and transdermal administration in safety assessments. Somacy-FP100, a related glycolipid extract, holds 'Generally Recognized as Safe' (GRAS) status by the FDA for food use (21 CFR §184.1277), with an established No-Observed-Adverse-Effect Level (NOAEL) of 4500 mg/kg body weight/day via oral intake. Although Pantoea agglomerans can be an opportunistic pathogen in specific, extreme contexts (e.g., severe immunocompromise or penetrating trauma), the refined cosmetic and food-grade extract is deemed safe.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This fermented extract is a valuable asset for precision skincare, offering robust immune-modulating and anti-inflammatory benefits that support skin regeneration and barrier function, particularly for sensitive and dry skin types.

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