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Moumoujus

PANTHENOL.

Valuable CAS 81-13-0 / 16485-10-2 / ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Panthenol, also known as provitamin B5, is a highly effective humectant and skin protectant. It transforms into pantothenic acid (Vitamin B5) upon absorption, working to deeply moisturize, enhance barrier function, and soothe irritation for healthier, more resilient skin.

Summary

soothing moisturizer/humectant skin protecting wound healing

Science

Mechanism of Action

Upon topical application, Panthenol penetrates the stratum corneum, where it is converted into pantothenic acid (Vitamin B5), a crucial component of coenzyme A. This coenzyme is vital for lipid metabolism and cellular energy production, thus supporting healthy skin function. Panthenol effectively attracts and binds water, acting as a potent humectant. It also strengthens the skin's natural barrier by stimulating lipid synthesis and promoting epidermal cell differentiation. Furthermore, Panthenol exhibits anti-inflammatory and soothing properties, and facilitates wound healing through stimulating fibroblast proliferation.

Research

Clinical Evidence

High confidence
Effective range 1–10%
Optimal

5%

Key findings

  1. 01 Demonstrated significant reduction in transepidermal water loss (TEWL) and improved skin moisture after 30 days, enhancing skin integrity and offering protective benefits.
  2. 02 Achieved significant reduction in TEWL and improved skin moisture over 30 days. This concentration also accelerated the healing of superficial wounds and effectively mitigated inflammation.
  3. 03 Provided profound, non-greasy moisturization and promoted skin repair. User studies indicated 93% reported 12-hour moisturization, 97% experienced hydration without greasiness, and 87% noted reduced irritation within two weeks.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
5.3%
Red flag below
5.3%

The Cosmetic Ingredient Review (CIR) Expert Panel concluded Panthenol is safe for use, with the highest reported concentration in leave-on body and hand products being 5.3%. While clinical studies demonstrate efficacy up to 10%, concentrations exceeding 5.3% should be carefully evaluated against established safety guidelines for the specific product type and application.

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

Aqueous solutions of D-Panthenol are most stable within a pH range of 3 to 7, with an optimum stability at pH 6. It is sensitive to heat; temperatures exceeding 70-75°C can induce racemization. Therefore, it is advised to incorporate Panthenol into formulations during the cool-down phase. Panthenol is also highly hygroscopic, requiring appropriate storage.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5.3%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel, alongside the U.S. FDA and European SCCS, deems Panthenol safe for cosmetic use. It is not classified as toxic, harmful, cytotoxic, immunotoxic, carcinogenic, or mutagenic. Rare instances of contact dermatitis or allergies have been reported.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Panthenol is a valuable ingredient, universally compatible and highly effective across a broad range of concentrations, offering comprehensive moisturizing, barrier-supporting, and soothing benefits with an excellent safety profile.

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References

Sources