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Moumoujus

PANAX NOTOGINSENG EXTRACT.

Valuable CAS 94279-78-4 / SKIN CONDITIONING

Panax Notoginseng Extract is a potent botanical ingredient renowned for its multifaceted skin benefits. Rich in saponins, it provides significant antioxidant and anti-inflammatory support, aiding in the neutralization of free radicals and protection against oxidative stress. Furthermore, it contributes to skin regeneration and is particularly noted for its potential in managing hyperpigmentation such as melasma.

Summary

Antioxidant Skin-conditioning Anti-inflammatory Skin regeneration Collagen booster Barrier strengthening Melanin inhibitor Circulation enhancer

Science

Mechanism of Action

This extract primarily functions through its saponin content, demonstrating robust antioxidant and anti-inflammatory effects. It actively alleviates oxidative stress, supports the synthesis of type I pro-collagen via the TGF-β/Smad signaling pathway, and fortifies the skin barrier. For hyperpigmentation like melasma, it reduces lipid peroxidation, enhances the skin's intrinsic antioxidant capacity, and inhibits tyrosinase activity. Additionally, it is believed to promote cutaneous microcirculation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A fermented Panax notoginseng extract, at 0.06 mg/mL, demonstrated a protective effect against H2O2-induced oxidative stress in mouse skin fibroblast cells, enhancing their antioxidant capacity.
  2. 02 Salvianolic acid B, a component derived from Panax notoginseng (in a combined formulation with Salvia miltiorrhiza) at 60–90 nmol/mL, inhibited tyrosinase activity in B16F10 cells, increased skin antioxidant capacity, reduced lipid peroxidation, and provided anti-inflammatory benefits, contributing to melasma mitigation.

Transparency

Dusting Analysis

Not commonly dusted

While the CIR noted a low reported concentration (0.0004%) for Panax notoginseng root in dentifrices, there is no specific data indicating a common practice of 'dusting' this extract in general cosmetic formulations for marketing purposes at ineffective levels. Efficacy concentrations for topical use are not broadly established from reported cosmetic uses.

The Formula

Formulation

Solubility
Water
Optimal pH ≥5
0 7 14

Stability

Fermented Panax notoginseng extract exhibits good stability with minimal changes in pH and soluble solids over four weeks. However, its active saponin components are sensitive to heat and can be inactivated during prolonged heating or concentration processes.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.0004%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel deemed Panax spp. root-derived ingredients, including Panax notoginseng root and root powder, safe for cosmetic use. The reported maximum concentration to the FDA for Panax notoginseng root is 0.0004% in dentifrices, with no other cosmetic uses reported. Oral intake during pregnancy or breastfeeding is considered likely unsafe due to potential birth defects observed in animals and estrogen-like activity; therefore, topical use should be approached with caution during these periods, and consultation with a healthcare professional is advised. Fermented Panax notoginseng extract has demonstrated appropriate safety in RBC and HET-CAM tests.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Panax Notoginseng Extract is a valuable botanical for skincare, offering comprehensive benefits from antioxidant and anti-inflammatory protection to support for collagen synthesis and hyperpigmentation reduction, all with a favorable safety profile for sensitive skin.

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