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Moumoujus

PALMITOYL PALMITAMIDE MEA.

Valuable CAS 208044-65-9 / HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

PALMITOYL PALMITAMIDE MEA is a skin-identical lipid component recognized for its ability to strengthen the skin's natural barrier. It effectively minimizes sensitivity and irritation while promoting optimal hydration, leading to enhanced skin health and elasticity.

Summary

Hair conditioning Humectant Skin conditioning Skin protecting Antistatic Foam boosting Viscosity controlling

Science

Mechanism of Action

This ingredient, also known as PEA Complex, fortifies the epidermal barrier by creating a protective film that significantly reduces transepidermal water loss, contributing to smoother skin texture and improved elasticity. Its anti-inflammatory properties are achieved through the down-regulation of mast cell activation and interaction with PPAR-α receptors, collectively mitigating skin sensitivity and reducing inflammatory responses.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–5%
Optimal

1%

Key findings

  1. 01 Demonstrated a reduction in skin irritation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 3.5 – 7
0 7 14

Stability

This ingredient exhibits stability within a pH range of 3.5 to 7.0. It can tolerate temperatures up to 80°C for brief durations, not exceeding 15 minutes; however, prolonged exposure above 80°C should be meticulously avoided to preserve its integrity.

Conflicts

  • Formulations prone to N-nitroso compound formation
  • Aerosol products (due to potential monoethanolamine (MEA) precursor)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined PALMITOYL PALMITAMIDE MEA to be safe when formulated to be non-irritating and when N-nitroso compounds are not formed in the product. It is considered unsafe by CIR for leave-on, non-rinse-off applications. For products intended for prolonged skin contact, the concentration should not exceed 5%. The precursor monoethanolamine (MEA) must not be included in aerosol formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PALMITOYL PALMITAMIDE MEA is a valuable barrier-supporting and irritation-reducing ingredient, particularly beneficial for dry and sensitive skin, with an optimal use rate of 1.0%, provided specific formulation restrictions are meticulously observed.

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