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PALMITOYL INULIN.

Insufficient Data CAS 195395-22-3 / SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMULSIFYING

Palmitoyl Inulin is a functionalized derivative of inulin, a natural polysaccharide recognized for its prebiotic properties. This ingredient is designed to rebalance the skin's microbiome, enhance hydration, and potentially provide emollient benefits, contributing to a robust and healthy skin barrier.

Prebiotic Skin Microbiome Balancer Humectant Hydrating Agent Emollient Skin Regenerator Emulsifier Stabilizer

Science

This ingredient operates primarily through its inulin component, acting as a selective prebiotic for the skin's microbiota. It encourages the proliferation of beneficial bacteria, such as *Staphylococcus epidermidis*, while concurrently inhibiting the growth of pathogenic strains like *Escherichia coli* and *Staphylococcus aureus*. This action helps restore a balanced skin microbiome, mitigating the risks associated with microbial dysbiosis. Furthermore, inulin functions as a humectant, actively drawing and retaining moisture within the skin to improve hydration levels. The bacterial metabolism of inulin also leads to the endogenous synthesis of carbonic acids, including lactic acid, which is vital for sustained skin hydration and supporting natural regeneration. The palmitoyl modification likely augments the ingredient's affinity for the skin's lipid barrier, potentially optimizing skin penetration and contributing emollient characteristics to the formulation.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH 5 – 12
0 7 14

Stability

The base ingredient, inulin, exhibits robust thermal stability up to 100°C under neutral pH conditions. However, its β-(2→1) linkages are susceptible to acid-catalyzed hydrolysis, particularly at pH levels ≤ 4. At pH ≥ 5, this fructan shows no degradation even with thermal processing. The palmitoyl modification imparts hydrophobic properties, suggesting Palmitoyl Inulin is likely amphiphilic or oil-soluble, lending itself to potential roles as an emulsifier or stabilizer in various formulations.


Safety

CIR Status
Insufficient data
Sensitization risk Unknown

While Palmitoyl Inulin is mentioned in a Cosmetic Ingredient Review (CIR) document related to polysaccharide gums, a specific, dedicated safety assessment or a 'safe as used' conclusion with a maximum concentration for Palmitoyl Inulin itself has not been established. The broader category of 'most polysaccharide gums' is generally deemed safe in cosmetic applications. Inulin, the foundational component, holds a Generally Recognized As Safe (GRAS) affirmation from the FDA for specific food categories. No SCCS assessment for Palmitoyl Inulin was identified.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

Palmitoyl Inulin exhibits promising mechanistic benefits for skin microbiome balance and hydration, however, dedicated safety assessments are currently insufficient to define precise usage parameters and a comprehensive safety profile.


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