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PALMITAMIDOPROPYLTRIMONIUM CHLORIDE.

Valuable CAS 51277-96-4 / ANTISTATIC, HAIR CONDITIONING

Palmitamidopropyltrimonium Chloride (PATC) is a cationic conditioning agent recognized for its ability to smooth and soften both skin and hair. Its amphiphilic nature allows it to adhere to negatively charged surfaces, providing antistatic benefits and a refined texture.

Summary

Antistatic Hair Conditioning Skin Conditioning Thickening Agent

Science

Mechanism of Action

This quaternary ammonium compound features an amphiphilic structure, comprising a hydrophobic tail and a permanently positive cationic trimethylammonium head. This positive charge facilitates substantive adsorption to anionic surfaces, such as the keratin found in skin and hair, thereby imparting conditioning and antistatic properties. Furthermore, it functions as a thickening agent within cosmetic formulations, contributing to desired product viscosity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Optimal stability and compatibility are observed within a slightly acidic to neutral pH range of 3.5 to 6.5. Exposure to strongly alkaline conditions can induce amide hydrolysis, necessitating pH validation during formulation.

Conflicts

  • Direct mixing with anionic surfactants, particularly when undiluted, can result in strong interactions leading to complexation or precipitation. Compatibility can be enhanced through prior dilution, strategic staging (e.g., adding to a pre-formed surfactant phase), or by co-formulating with amphoteric or nonionic surfactants to maintain clarity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While generally considered safe for cosmetic use, the Cosmetic Ingredient Review (CIR) and Scientific Committee on Consumer Safety (SCCS) have not published specific safety assessments for Palmitamidopropyltrimonium Chloride. Isolated instances of skin irritation, allergic reactions, or contact dermatitis are possible. The Environmental Working Group (EWG) flags moderate concern for respiratory issues and some concern for skin irritation and potential developmental/reproductive toxicity, often based on structurally similar quaternary ammonium compounds. GHS classification for the raw material suggests potential for severe skin burns and eye damage, necessitating careful handling of the concentrated form. A patch test is advisable prior to widespread application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Low

Our Assessment

Verdict

Valuable

Palmitamidopropyltrimonium Chloride is a valuable conditioning and antistatic agent, enhancing skin smoothness and hair manageability, though its potential for irritation warrants careful consideration for sensitive skin types and specific formulation practices.

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