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PALMAMIDOPROPYLTRIMONIUM CHLORIDE.

Avoid / HAIR CONDITIONING

Palmitamidopropyltrimonium Chloride (PATC) is a quaternary ammonium compound with an amphiphilic structure. It is primarily used for its conditioning and antistatic properties, binding to negatively charged surfaces in hair and, to a lesser extent, skin.

antistatic hair conditioning skin conditioning

Science

This compound features a C16 (palmitoyl) hydrophobic tail and a cationic trimethylammonium head, connected via a propylamido spacer. This unique structure allows it to substantively adsorb to anionic sites present on keratin in both hair and skin, thereby imparting conditioning effects and reducing static electricity.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Optimal stability and compatibility within formulations are observed in a slightly acidic to neutral pH range of 3.5 to 6.5. Exposure to strongly alkaline systems can induce amide hydrolysis, potentially compromising the ingredient's structural integrity and efficacy.


Safety

CIR Status
Not reviewed
Sensitization risk High

PubChem data indicates significant safety concerns, classifying this ingredient as harmful if swallowed (H302), causing severe skin burns and eye damage (H314), and serious eye damage (H318). It is also noted as very toxic to aquatic life (H400). The EPA TSCA lists its commercial activity status as 'ACTIVE'.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

While offering conditioning and antistatic benefits, the documented high irritancy and potential for severe skin and eye damage make this ingredient unsuitable for precision skincare formulations.


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