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P-METHYLAMINOPHENOL SULFATE.

Avoid CAS 150-75-4 / HAIR DYEING

P-Methylaminophenol Sulfate is an organic compound predominantly utilized as a primary intermediate in permanent oxidative hair dyeing processes. It functions by reacting inside the hair fiber to develop color, leveraging its inherent reducing capacity. This ingredient finds no documented beneficial applications in precision skincare.

Summary

Hair Colorant

Science

Mechanism of Action

P-Methylaminophenol Sulfate acts as a reducing agent, undergoing oxidation to quinone-like or imine-type products, which is fundamental to its role in color formation within hair fibers. While this mechanism is critical for its efficacy as a hair dye, no direct beneficial mechanisms on skin are identified; its interaction with skin is primarily associated with potential irritation and sensitization.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

P-Methylaminophenol Sulfate is not an active ingredient intended for leave-on skincare formulations where 'dusting' would be a relevant consideration. Its primary application is as a hair colorant, with concerns on skin related to sensitization rather than efficacy at low concentrations.

The Formula

Formulation

Solubility
Water
Optimal pH ≤7
0 7 14

Stability

This ingredient is stable in solid, sealed form but is highly susceptible to oxidation and discoloration upon exposure to air, moisture, alkali, or light. Solutions should be prepared freshly or include effective antioxidants and stabilizers. For optimal solution stability, an acidic pH generally below 7.0 is recommended.

Conflicts

  • Strong oxidizing agents
  • Acid anhydrides
  • Acid halides
  • Acids
  • Light
  • Strong heating
  • Heavy metal contaminants

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1.5%
Sensitization risk Moderate

The CIR Expert Panel considers P-Methylaminophenol Sulfate safe for use as a hair dye ingredient, with authorized in-use concentrations up to 1.5% (or 0.68% on-head). However, it is classified as a moderate skin sensitizer, carrying a risk of allergic skin reactions. It is also identified as harmful if swallowed and may cause damage to organs with prolonged or repeated exposure. As a secondary amine, it exhibits a propensity for nitrosation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

P-Methylaminophenol Sulfate is a potent hair dye intermediate with established moderate skin sensitizing potential and no known benefits for skin, rendering it unsuitable for precision skincare formulations.

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