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Moumoujus

P-MENTHANONE.

Avoid CAS 10458-14-7 / PERFUMING

P-Menthanone, also known as Menthone, is an organic compound primarily recognized for its aromatic properties. While it can enhance skin permeability by altering the stratum corneum's lipid structure, its application in skincare is severely limited by a notable risk of irritation and sensitization.

Summary

perfuming skin penetration enhancer

Science

Mechanism of Action

P-Menthanone functions as a skin penetration enhancer. It facilitates the absorption of other substances by disrupting the ordered organization of stratum corneum lipids and partially extracting them, thereby increasing skin permeability.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

For optimal stability, store in tightly sealed containers in a cool, dry place, shielded from both heat and light. Decomposition, typically under heat, can lead to the emission of acrid smoke and irritating fumes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

P-Menthanone is classified by ECHA as a skin irritant (H315) and a skin sensitizer (H317), indicating it can cause irritation and allergic skin reactions. The Research Institute for Fragrance Materials (RIFM) considers it a skin sensitizer, with a No Expected Sensitization Induction Level (NESIL) of 10000 µg/cm². RIFM also concluded it is not genotoxic and not expected to be photoirritating or photoallergenic. The Margin of Exposure (MOE) for repeated dose toxicity and reproductive toxicity is reported as >100. The FDA lists p-Menthan-3-one as a flavoring agent or adjuvant.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its high potential for causing skin irritation and sensitization, P-Menthanone is generally not recommended for use in precision skincare formulations, despite its documented ability to enhance skin penetration.

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References

Sources