Science
Mechanism of Action
P-CHLOROPHENOL infiltrates skin and epithelial layers with ease. Its primary mode of action involves the uncoupling of oxidative phosphorylation, a critical cellular process, leading to the disruption of energy production and resulting in severe tissue damage and necrosis.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
P-CHLOROPHENOL is a banned and toxic substance in cosmetic applications, rendering the concept of 'dusting' irrelevant for this ingredient.
The Formula
Formulation
Stability
P-CHLOROPHENOL exhibits solubility in water, ranging from approximately 2.7 g/100ml at 20°C to 27.1 g/L. It is also soluble in ethanol. The compound is thermally sensitive, liquefying and darkening in color at temperatures above 42°C (108°F). A 1% solution demonstrates an acidic pH, with a pKa of 9.41.
Conflicts
- acid chlorides
- acid anhydrides
- oxidizing agents
- iron
Safety
Safety Profile
P-CHLOROPHENOL is identified as a human skin toxicant and allergen, with strong evidence of irritancy. The Cosmetic Ingredient Review (CIR) assessed related chlorophenol compounds, noting insufficient safety data and their ban by the European Commission. The EU Cosmetics Directive explicitly bans P-CHLOROPHENOL, and the FDA prohibits cosmetic ingredients that render a product harmful under normal use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
P-CHLOROPHENOL is a highly toxic, irritating, and sensitizing substance that is explicitly banned from cosmetic use due to its documented potential to cause severe skin damage and cellular necrosis.
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References
Sources