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P-AMINOPHENOL SULFATE.

Avoid CAS 63084-98-0 / HAIR DYEING

P-AMINOPHENOL SULFATE is a salt derived from p-aminophenol, primarily recognized for its role as an oxidative hair dye precursor. While its parent compound is deemed safe within strict concentration limits for specific cosmetic applications, its inherent properties raise significant concerns for general skincare use.

Summary

Hair Dye

Science

Mechanism of Action

The parent compound, p-aminophenol, primarily functions as an oxidative hair dye precursor, where the final color develops through a chemical reaction. When applied topically to the skin, p-aminophenol can be N-acetylated, metabolically converting into acetaminophen (APAP).

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 P-aminophenol, the parent compound, demonstrated irritancy on normal skin.
  2. 02 This is the maximum on-head concentration authorized for p-aminophenol in oxidative hair dye formulations, after mixing with an oxidative agent.

Transparency

Dusting Analysis

Commonly dusted
Red flag below
0%

P-AMINOPHENOL SULFATE's parent compound is classified as a mutagen category 2 (CLP) and is suspected of causing genetic defects. It is also a known skin irritant and sensitizer. Consequently, its presence in any skincare formulation, regardless of concentration, constitutes a red flag due to these inherent risks, making its use in such products highly questionable.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The parent compound, p-aminophenol, is unstable; it deteriorates and turns violet when exposed to air and light. It oxidizes readily in the presence of a base. A related compound, p-methylaminophenol sulphate, is a secondary amine prone to nitrosation.

Conflicts

  • strong acids
  • acid chlorides
  • acid anhydrides
  • strong oxidizing agents
  • bases
  • air
  • light
  • moisture

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.9%
Sensitization risk High

While European and American experts consider p-aminophenol safe for use within the specific concentrations authorized for hair and eyelash colouring products, it is classified as a mutagen category 2 (CLP) and is suspected of causing genetic defects. It is also known to be irritating and sensitizing to the skin, with warnings against use on skin with rashes, sensitivity, irritation, or scalp lesions.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a suspected mutagen and high risk of skin irritation and sensitization, P-AMINOPHENOL SULFATE is unsuitable and should be avoided in all skincare formulations.

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