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Moumoujus

OZONIZED PEG-10 OLEATE.

Questionable CAS - / ANTIMICROBIAL, CLEANSING, SURFACTANT - CLEANSING

OZONIZED PEG-10 OLEATE is an ozonated oil derivative valued for its multifaceted germicidal, immune-stimulating, and tissue-restoring properties in topical applications. It acts primarily as a potent antimicrobial agent, created through the ozonation of PEG-10 Oleate.

Summary

Antimicrobial Bactericidal Fungicidal Virucidal Immune Stimulant Tissue Restorative

Science

Mechanism of Action

This ingredient exerts its germicidal properties through the oxidation of microbial cell walls and cytoplasmic membranes, enhancing permeability and facilitating the entry of ozone into bacterial cells. The resulting ozonides are responsible for its germicidal, immune-stimulating, and tissue-restoring effects. It further stimulates the innate immune system, as microbial lipoproteins generate lipid oxidation products (LOPs) that elevate hydrogen peroxide (H2O2) levels in phagocytes, boosting bacteriostatic and bactericidal activity.

Research

Clinical Evidence

Medium confidence
Effective range 1–6%
Optimal

3%

Key findings

  1. 01 Clinical studies on ozonated oils, broadly demonstrating therapeutic efficacy, indicate bactericidal, fungicidal, and virucidal effects across various dermatological conditions including skin infections, dermatitis, fungal issues, and chronic ulcers. While not specific to OZONIZED PEG-10 OLEATE, suggested concentrations for general ozonated oils range from 1-2% for lip balms, 2-3% for moisturizers, 3-4% for cleansers and anti-aging products, and up to 5-6% for medical applications.

Transparency

Dusting Analysis

Not commonly dusted

No data regarding 'dusting' or typical ingredient concentration levels that might lead to dusting was found for this ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Ozonides require precise storage conditions for commercial viability. Stability of at least six months has been observed for some ozonated oils at refrigerated or room temperatures; however, ozonide content significantly declines at 40°C or over extended periods. Exposure to light and moisture can lead to decomposition, aldehyde formation, and objectionable odors due to rancidity. Formulators should also note its potentially unpleasant smell and high viscosity, often necessitating 10-20x dilution and the incorporation of masking agents. Advanced delivery systems such as nanoemulsions and microemulsions are employed to optimize activity and mitigate undesirable effects.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

Specific regulatory status from CIR, SCCS, or FDA for OZONIZED PEG-10 OLEATE is currently unavailable. While its non-ozonized precursor, PEG-10 Oleate, is considered safe under specific conditions (avoiding inhalable forms and ensuring absence of toxic impurities like 1,4-dioxane), the ozonized derivative raises notable concerns. There is a documented likelihood of irritation, which escalates when combined with other problematic ingredients, potentially leading to irritation, inflammation, and dryness. Furthermore, the ozonation process itself can generate formaldehyde, a byproduct known for its toxicity and potential to interfere with cellular integrity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite the broad antimicrobial and tissue-restoring potential observed with ozonated oils, the lack of specific safety data for OZONIZED PEG-10 OLEATE, its high irritancy risk, and the potential formation of toxic byproducts make its inclusion in cosmetic formulations highly questionable.

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