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OXACYCLOHEPTADEC-10-EN-2-ONE.

Questionable CAS 28645-51-4 / PERFUMING

This synthetic macrocyclic musk imparts a warm, soft musk aroma with subtle nuances of ambergris, florals, and fruit. Primarily functioning as a fragrance component, it also serves as an effective fixative, enhancing the longevity of delicate scent profiles.

Fragrance

Science

OXACYCLOHEPTADEC-10-EN-2-ONE primarily functions as a fragrance ingredient, contributing a distinctive warm musk scent. Its secondary mechanism is that of a fixative, which stabilizes more volatile fragrance components, thereby extending the overall scent impression, particularly in floral or mild animal/amber-like compositions.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

As a component purely for fragrance, OXACYCLOHEPTADEC-10-EN-2-ONE is included for its aromatic properties rather than a direct skin benefit. Therefore, the concept of 'dusting' (underdosing an active ingredient for efficacy) does not apply to this ingredient.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient exhibits good stability across various common product formulations including body lotions, shampoos, soaps, concentrated detergent powders, and antiperspirants (up to 15%). It presents no significant reactivity hazard by itself or in contact with water.

Conflicts

  • bleaches

Safety

CIR Status
Insufficient data
Sensitization risk High

The Research Institute for Fragrance Materials (RIFM) is in the process of completing a comprehensive safety assessment. It has been identified as potentially causing an allergic skin reaction (Skin Sens. 1B) according to GHS classification. In in vitro chromosome aberration assays, it was found to be non-clastogenic at concentrations up to 2380 µg/mL and 2280 µg/mL. No component at levels ≥ 0.1% is identified as a probable, possible, or confirmed human carcinogen by IARC, OSHA, or NTP. The FDA lists it as a food additive with limited toxicity data, and it is also categorized as a flavoring agent and food additive by JECFA and EPA TSCA.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Due to its sole function as a fragrance, an identified potential for allergic skin reactions (Skin Sens. 1B), and its 'insufficient data' CIR status, its inclusion in precision skincare formulations is highly questionable.


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