Science
Mechanism of Action
This extract demonstrates anti-melanogenic activity by down-regulating key components in the melanin synthesis pathway, specifically targeting microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related proteins-I and -II within B16F10 melanoma cells. Its mechanism involves inhibiting the phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein and certain mitogen-activated protein kinases (MAPKs), specifically p38 and c-Jun N-terminal kinase, while simultaneously promoting the phosphorylation of extracellular regulated protein kinases (ERKs). The parent plant is also noted for adaptogenic, anti-inflammatory, and antioxidant benefits, with flavonoids contributing significantly to its antioxidant profile.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Inhibited tyrosinase activity and melanin content in B16-F10 melanoma cells.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract is typically prepared using hydroalcoholic solvents, such as 70% ethanol, indicating good solubility in both aqueous and ethanolic formulations. The culture medium for Oplopanax elatus adventitious roots is typically maintained at a pH of 5.8 during cultivation.
Safety
Safety Profile
No specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA are currently available for Oplopanax Elatus Callus Culture Extract. A lack of comprehensive safety data for cosmetic applications has been noted, with some sources indicating it is 'Not rated' and has 'No known benefits' in their ingredient dictionaries.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising in-vitro anti-melanogenic and antioxidant properties, the lack of comprehensive safety reviews and human clinical data warrants caution, leading to an 'insufficient data' rating for broad recommendation.
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