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Moumoujus

OLIGOPEPTIDE-91 RH-OLIGOPEPTIDE-1.

Insufficient Data / SKIN CONDITIONING, SKIN PROTECTING

Oligopeptide-91 Rh-Oligopeptide-1 is a sophisticated fusion peptide engineered for advanced skin conditioning and robust protection. It integrates a 21-amino acid synthetic peptide (Oligopeptide-91) with rh-Oligopeptide-1, a bioengineered form of Epidermal Growth Factor (EGF), to activate the skin's intrinsic repair mechanisms.

Summary

Skin conditioning Skin protecting Anti-aging Skin regeneration Wound healing Improves skin texture Reduces fine lines Enhances elasticity Brightening Hydration

Science

Mechanism of Action

This dual-component peptide functions by signaling the skin to activate its natural regenerative processes. The rh-Oligopeptide-1 component, recognized as Epidermal Growth Factor (EGF), precisely binds to specific cellular receptors, thereby stimulating the proliferation and differentiation of epidermal cells. This action promotes endogenous collagen and elastin synthesis, significantly enhances the skin barrier, improves hydration, and modulates inflammatory responses. Simultaneously, the Oligopeptide-91 segment contributes to refining skin texture, improving smoothness, and enhancing overall complexion.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

The rh-Oligopeptide-1 (EGF) component exhibits high sensitivity to pH fluctuations and is susceptible to enzymatic degradation by microorganisms. Strict microbial contamination control is imperative during processing. For optimal stability, it should be incorporated into formulations during the final production stage at temperatures maintained below 40℃.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not yet assessed Oligopeptide-91 Rh-Oligopeptide-1. While sh-Oligopeptide-1 (EGF) is authorized for general cosmetic use in various concentrations, long-term safety data remains unknown. Significant concerns exist regarding EGF's mitogenic (cell proliferation stimulating) properties, as it could potentially promote the spread or abnormal growth of existing cancerous cells, or exacerbate conditions in individuals with high skin cancer risk factors or psoriasis.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While demonstrating a promising mechanistic basis for skin regeneration and conditioning, a 'insufficient-data' rating is assigned due to the lack of specific clinical studies for this combined ingredient and the significant, unaddressed safety concerns regarding the mitogenic potential of its EGF component.

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