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Moumoujus

OLIGOPEPTIDE-41.

Valuable CAS - / SKIN CONDITIONING

Oligopeptide-41 is a synthetic biomimetic peptide engineered to address hair loss by preserving follicular health and stimulating hair growth. It also contributes to enhanced skin barrier function, elasticity, and hydration, leveraging its amino acid profile for comprehensive dermal support.

Summary

hair-growth promoting skin conditioning improves skin elasticity enhances skin barrier function moisturizing anti-hair loss

Science

Mechanism of Action

This peptide operates primarily by inhibiting Dickkopf 1 (DKK-1), a known antagonist of the WNT signaling pathway crucial for hair follicle development and maintenance. By neutralizing DKK-1, Oligopeptide-41 helps safeguard hair follicles from degeneration, boosts hair follicle cell proliferation and migration, and mitigates UV-induced cellular apoptosis. For skin, its synergistic amino acid composition is understood to fortify the epidermal barrier, leading to improvements in skin elasticity and moisture retention, in part by targeting Epidermal Growth Factor Receptor (EGFR).

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Oligopeptide-41 is water-soluble, facilitating its incorporation into aqueous formulations. While its specific optimal pH range is not detailed, similar oligopeptides typically exhibit stability within a pH range of 5 to 7. For optimal preservation, it is generally advised to integrate this ingredient during the final phase of manufacturing, ensuring temperatures remain below 45°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Oligopeptide-41 has not undergone formal review by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). While no specific FDA status for this cosmetic ingredient is available, the broader category of oligopeptides often demonstrates favorable safety profiles, with independent studies on related peptides like Oligopeptide-10 reporting non-cytotoxic, non-mutagenic, non-irritating, and non-sensitizing properties. However, these generalized findings cannot be directly extrapolated to Oligopeptide-41 without specific assessment.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Oligopeptide-41 presents as a valuable peptide with a clear mechanistic pathway for promoting hair health and reported benefits for skin barrier function and elasticity, though specific quantitative clinical efficacy data remains to be detailed.

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References

Sources