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Moumoujus

OLIGOPEPTIDE-34.

Valuable CAS - / SKIN CONDITIONING

Oligopeptide-34 is a multi-functional biomimetic peptide engineered to address diverse skin concerns, primarily targeting hyperpigmentation. Beyond its significant skin-lightening capabilities, it also contributes to anti-aging benefits through collagen and elastin promotion, alongside anti-inflammatory effects.

Summary

Skin-lightening Anti-aging Antioxidant Anti-inflammatory Melanin reduction Tyrosinase inhibition Collagen booster Elastin booster

Science

Mechanism of Action

Oligopeptide-34 operates through a sophisticated multi-pathway mechanism to regulate pigmentation. It actively decreases melanin synthesis by down-regulating crucial enzymes and proteins such as TRP-1, TRP-2, MITF, and Tyrosinase. Further, it prevents the transfer of melanosomes from melanocytes to keratinocytes, a critical step in the pigmentation process. The peptide also promotes the breakdown of melanocyte-stimulating hormone (MSH), thereby limiting tyrosinase activity. Beyond pigmentation, Oligopeptide-34 exhibits anti-inflammatory properties by reducing TH1-type pro-inflammatory cytokines and dermal lymphocyte proliferation. It also stimulates the differentiation and proliferation of fibroblasts, leading to increased production of collagen, elastin, and fibronectin, which are vital for enhancing skin integrity, firmness, and elasticity.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Laboratory studies on melanocyte cultures demonstrated that formulations containing Oligopeptide-34 significantly reduce melanin content and limit tyrosinase activity in a dose-dependent manner.
  2. 02 In human melanocyte laboratory studies, Oligopeptide-34 significantly reduced melanin production by approximately 33%.
  3. 03 Optimized concentrations of Oligopeptide-34 led to a substantial 65% reduction in Tyrosinase enzyme activity in studies.
  4. 04 A clinical study involving 22 Asian individuals applying Oligopeptide-34 twice daily showed a statistically significant brightening of pigmented spots, reducing pigmentation by 47%. This compared favorably to Vitamin C (27%) and Arbutin (40%).
  5. 05 When incorporated into a mesotherapy peptide blend and applied topically with microneedling over approximately 3 months (five bi-weekly sessions), patients with melasma experienced a significant reduction in their Modified Melasma Area and Severity Index (mMASI) score, decreasing from 9.2 ± 5.7 at baseline to 3.6 ± 4.0 after treatment.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Oligopeptide-34 maintains stability for 24 months from its manufacture date when stored in a freezer at -20°C to -15°C, protected from light, and kept air-proofed when not in use.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally regarded as a safe and effective ingredient for skincare, manufacturers state it is free of heavy metals and does not cause skin or eye irritation. INCIDecoder rates its irritancy as low.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Oligopeptide-34 is a valuable ingredient, demonstrating significant efficacy in reducing hyperpigmentation, inhibiting tyrosinase activity, and enhancing skin integrity across various clinical and laboratory settings, with a low risk of irritation.

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