Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

OLIGOPEPTIDE-177 TRIFLUOROACETATE.

Questionable / SKIN PROTECTING

Oligopeptide-177 Trifluoroacetate is a synthetic 33-amino acid peptide engineered to mimic erythropoietin's regenerative properties without its hematopoietic effects. It functions as a potent tissue-protective and regenerative agent, addressing signs of aging, acne, and UV-induced irritation.

Summary

Tissue Protective Regenerative Promotes Skin Regeneration Promotes Skin Renewal Wound Healing Support Anti-Aging Anti-Acne Anti-UV Induced Irritation

Science

Mechanism of Action

This synthetic peptide specifically targets the CD90 receptor found on skin keratinocytes and fibroblasts. By binding, it orchestrates a cascade of regenerative processes including enhanced skin cell renewal, accelerated wound healing, improved microvessel formation, optimized oxygen and nutrient delivery to tissues, and the stimulation of crucial growth factors.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Manufacturer's clinical trials indicate significant beneficial effects against signs of skin aging, alleviating acne symptoms, and mitigating UV-induced irritation.
  2. 02 It is a key active component within Augustinus Bader's patented Trigger Factor Complex (TFC), widely used in their skincare formulations.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Synergies

  • Effectively delivered via a lipid structure with ceramides, accompanied by amino acids that act as triggering agents, as observed in Augustinus Bader's TFC.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Oligopeptide-177 Trifluoroacetate has not undergone specific review by the Cosmetic Ingredient Review (CIR) or the SCCS. The 'trifluoroacetate' component is a fluorinated compound classified as a potential PFA (Per- and Polyfluoroalkyl Substance), known for persistence and potential health concerns. A related ingredient containing trifluoroacetate (Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate) has received an alarming EWG safety rating of 10 (unsafe), highlighting a general concern with this counterion, though this specific rating is not directly assigned to Oligopeptide-177 Trifluoroacetate.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While Oligopeptide-177 Trifluoroacetate demonstrates potent regenerative and protective skin benefits in manufacturer trials, its classification with a trifluoroacetate counterion raises significant concerns regarding potential PFA presence and overall safety, pending independent review.

Related

Similar Ingredients

Finding similar ingredients…