Science
Mechanism of Action
This 33-amino-acid synthetic peptide, derived from the erythropoietin (EPO) glycoprotein, is engineered to be non-erythropoietic while retaining potent tissue-protective and regenerative capabilities. It precisely binds to the CD90 receptor found on skin keratinocytes and fibroblasts. This interaction initiates a cascade of beneficial cellular responses, including accelerated skin regeneration and renewal, enhanced wound healing, and stimulation of new microvessel formation. The result is improved oxygen and nutrient delivery to regenerating tissues, coupled with an increase in vital growth factor generation, collectively leading to skin recovery with minimal scar formation. Furthermore, Oligopeptide-177 provides cellular protection by inhibiting apoptosis (programmed cell death).
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Manufacturer's clinical trials indicated significant improvements across multiple skin concerns, including signs of aging, acne, and irritation resulting from UV exposure.
- 02 A patent application study involving a limited cohort of five subjects reported significant beneficial effects against indicators of skin aging, acne manifestations, and UV-induced irritation.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has not yet reviewed Oligopeptide-177, the FDA's involvement with cosmetic ingredients is typically reserved for undesirable side effects or medicinal claims. SkinSAFE categorizes Oligopeptide-177 as 'Irritant Free' and 'Oil Free', suggesting a low irritation potential.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Oligopeptide-177 is a valuable regenerative peptide, offering significant benefits for skin aging, acne, and irritation, though further independent and concentration-specific clinical data would enhance its profile.
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References
Sources