Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

OLIGOPEPTIDE-127.

Insufficient Data / SKIN CONDITIONING

Oligopeptide-127 is a short-chain amino acid sequence designed to act as a cellular signaling peptide. It supports the skin's intrinsic repair mechanisms, targeting concerns such as reduced elasticity, diminished plumpness, and visible pore size by modulating collagen and elastin production.

Summary

Skin-Conditioning Skin-identical ingredient Cell-communicating ingredient

Science

Mechanism of Action

Functioning as a cell-communicating ingredient, Oligopeptide-127 is theorized to penetrate the skin barrier and activate internal repair processes. Although specific research on Oligopeptide-127 is limited, oligopeptides as a class are known to interfere with the regulation of collagen and elastin, improving skin laxity and firmness. Related peptides, such as rh-Oligopeptide-1 (EGF), further demonstrate abilities to stimulate cell renewal, promote healing without scarring, enhance skin barrier function, and potentially reduce inflammation while boosting extracellular matrix components for long-term moisturization and regeneration.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

This peptide, like related variants, exhibits high sensitivity to pH; therefore, optimal stability and activity are maintained within a pH range of 5.0 to 8.0. Furthermore, preventing microbial contamination is crucial as enzymes from microorganisms can decompose the peptide. Given the generally poor membrane permeability of peptides, innovative delivery systems such as nano-systems are often explored to enhance bioavailability and stability.

Conflicts

  • microbial contamination (due to enzyme decomposition)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

There is currently no specific CIR report or SCCS opinion available for Oligopeptide-127. It is sometimes associated with or conflated with sh-Oligopeptide-1 (Epidermal Growth Factor, EGF). While EGF is an authorized cosmetic ingredient, concerns exist regarding the scientific basis of its preclinical bioactivity and potential unknown long-term risks in cosmetic applications, with active EGF frequently classified as an unauthorized drug rather than a cosmetic.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While oligopeptides offer promising skin benefits, the lack of specific safety and efficacy data for Oligopeptide-127 itself, coupled with its problematic association with EGF, necessitates a cautious approach.

Related

Similar Ingredients

Finding similar ingredients…