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Moumoujus

OLIGOPEPTIDE-118.

Valuable / SKIN CONDITIONING

Oligopeptide-118 is a bioactive peptide demonstrated in clinical trials to significantly reduce erythema, particularly in moderate to severe cases. It works by targeting and constricting enlarged blood vessels in the skin, offering a precise approach to redness reduction.

Summary

Reduces Erythema Skin Conditioning

Science

Mechanism of Action

Col-118, a formulation related to Oligopeptide-118, is understood to mitigate facial erythema primarily through the vasoconstriction of enlarged blood vessels within the facial tissue. This action directly addresses the vascular component of skin redness.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While specific stability data for Oligopeptide-118 is not directly available, related peptides such as Oligopeptide-1 are highly sensitive to pH, often requiring a range of 5-8 for optimal stability. They can also be decomposed by enzymes or microorganisms, potentially leading to activity loss. Similar considerations regarding pH and microbial control may be relevant for Oligopeptide-118.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No direct safety assessments have been conducted by the Cosmetic Ingredient Review (CIR), SCCS, or FDA specifically for Oligopeptide-118. The CIR Panel has previously noted that for other palmitoyl oligopeptide ingredients, a comprehensive safety evaluation requires detailed information on amino acid sequences and potential activities, such as angiogenesis stimulation, due to varying terminologies. Clinical trial data showed a side effect profile similar to the vehicle control, suggesting low acute irritation potential in that context.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Oligopeptide-118 holds valuable potential for targeted erythema reduction, supported by positive Phase 2 clinical trial results demonstrating a dose-response effect. However, comprehensive safety reviews, precise optimal concentrations, and detailed formulation stability data specific to this peptide are yet to be fully established.

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