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OLIGOPEPTIDE-107 SH-OLIGOPEPTIDE-1.

Valuable / SKIN CONDITIONING

OLIGOPEPTIDE-107 SH-OLIGOPEPTIDE-1, primarily recognized by its SH-Oligopeptide-1 component, is a bioengineered Epidermal Growth Factor (EGF) that acts as a potent cellular signaling molecule. It is designed to precisely stimulate skin regeneration and repair processes, leading to measurable improvements in texture, elasticity, and overall complexion.

Summary

Skin Regeneration Anti-Aging (reduces fine lines and rhytids) Improves Skin Texture Reduces Pore Size Evens Skin Tone (reduces dyschromia) Reduces Hyperpigmentation (e.g., melasma) Decreases Inflammatory Acne Lesions Boosts Collagen Synthesis Enhances Elastin Synthesis Improves Skin Firmness and Elasticity Soothing and Anti-Inflammatory Improves Skin Barrier Function Supports Wound Healing

Science

Mechanism of Action

Acting as a key signaling molecule, SH-Oligopeptide-1 precisely targets Epidermal Growth Factor (EGF) receptors on the surface of skin cells. This specific binding initiates a complex intracellular cascade, promoting the proliferation and differentiation of epidermal cells, thereby accelerating cellular turnover. The peptide actively enhances the biosynthesis of crucial extracellular matrix components, including collagen and elastin, which are vital for maintaining skin firmness and elasticity. Furthermore, its potent anti-inflammatory properties contribute to soothing irritated skin, improving barrier function, and aiding in scar reduction.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Data not available to assess dusting potential or typical market concentrations for this specific compound.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

Oligopeptide-1 (EGF) is highly sensitive to pH; precise pH adjustment of the cream to within 5.0-8.0 is crucial before adding a diluted EGF solution. It is also susceptible to enzymatic decomposition by microorganisms, necessitating stringent control over microbial contamination during processing. The ingredient should be incorporated in the final formulation step, ensuring temperatures remain below 45℃. As a medium-sized, polar molecule, a specialized delivery system may be required for optimal dermal penetration.

Conflicts

  • Microbial contamination (leads to decomposition and loss of activity)
  • Extreme pH values outside the 5.0-8.0 range
  • High temperatures (above 45℃ during addition)

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Low

While the combined INCI name OLIGOPEPTIDE-107 SH-OLIGOPEPTIDE-1 lacks a direct CIR review, the SH-Oligopeptide-1 (EGF) component is generally considered safe for cosmetic use, being biodegradable and free from animal-derived materials. Current research suggests that topically applied growth factors do not penetrate deeply enough to influence systemic cell growth. A recent literature review found no evidence that topical recombinant human EGF stimulates cancer cell proliferation, noting that EGF is mitogenic (stimulates cell proliferation) but not mutagenic. However, individuals with psoriasis or elevated skin cancer risk factors should consult a healthcare professional. It is not found on EWG's Restricted or Unacceptable Lists and is not considered carcinogenic in humans.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This peptide offers significant clinical promise for targeted skin concerns like aging, hyperpigmentation, and acne, operating through precise cellular signaling, although comprehensive long-term safety data in cosmetic applications is still evolving and warrants consideration.

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