Science
Mechanism of Action
Oleuropein Aglycone functions as a robust antioxidant by effectively scavenging free radicals and mitigating reactive oxygen species (ROS), thereby reducing oxidative DNA damage and cellular stress. Its anti-inflammatory prowess stems from its ability to reduce cell infiltration, inhibit cyclooxygenase (COX) enzymes, and suppress the production of inflammatory mediators such as COX-2, VEGF, and leukotriene B4, including lypoxygenase activity. For anti-aging, it inhibits Matrix Metalloproteinases (MMPs), specifically MMP-2, MMP-9, and MMP-13, which are key enzymes responsible for collagen degradation, thus maintaining skin structure, elasticity, reducing wrinkles, and decreasing skin thickening. Furthermore, it promotes wound healing by enhancing collagen fiber deposition and supporting re-epithelialization, and improves skin barrier function by reducing transepidermal water loss and attenuating UVB-induced erythema.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In an in vitro study, Oleuropein Aglycone exhibited anti-inflammatory effects on senescent endothelial and small airway epithelial cells, demonstrating effects on cell viability, at concentrations ranging from 1 µM (0.36 µg/mL) to 100 µM (36 µg/mL).
- 02 Its precursor, Oleuropein, was shown to lower intracellular melanin content in B16F10 cells by 24.48% to 27.71% when applied at concentrations of 100 µg/mL, 150 µg/mL, and 200 µg/mL.
Transparency
Dusting Analysis
The provided data does not indicate that pure Oleuropein Aglycone is commonly 'dusted' in cosmetic formulations. While its precursor is present in olive leaf extracts, which have reported uses up to 2%, there is no evidence suggesting its use purely for marketing claims at sub-efficacious levels as an isolated compound.
The Formula
Formulation
Stability
Oleuropein Aglycone's precursor, Oleuropein, demonstrates optimal stability around pH 5, maintaining good stability also at pH 3, but showing reduced stability at pH 7 and pH 9. Enzymatic hydrolysis to Oleuropein Aglycone is observed at pH 6.5. This ingredient is sensitive to high temperatures, with degradation occurring at 80°C or 110°C, potentially leading to a decrease in pH. Formulations incorporating olive leaf extract, a source of Oleuropein Aglycone, have shown stable homogeneous appearance and effectiveness for up to one year at room temperature. Strong acids and bases can also lead to degradation.
Conflicts
- Strong acids (can cause degradation)
- Strong bases (can cause degradation)
- High temperatures (can lead to degradation)
Safety
Safety Profile
The CIR Expert Panel concluded that 16 *Olea europaea* (olive)-derived ingredients, which contain oleuropein aglycone, are safe for use in cosmetics under current practices and concentrations. The maximum reported concentration for an olive leaf extract (a source) is 2% in suntan products and 0.002% in other skincare preparations. This safety assessment does not cover use in airbrush delivery systems. No specific SCCS or independent FDA status was found for pure Oleuropein Aglycone, though olive oil and olive leaf extracts are generally considered safe.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Oleuropein Aglycone is a versatile polyphenol offering significant antioxidant, anti-inflammatory, and anti-aging benefits, making it a valuable ingredient for comprehensive skin health and rejuvenation.
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References
Sources