Science
Mechanism of Action
As an analog of natural ceramides, Oleoyl Oleamide Serinol integrates into the skin's lipid matrix. It acts as an agonist for the GPR119 cannabinoid receptor and is posited to activate CB1 receptors, thereby stimulating the skin's intrinsic ceramide synthesis. This dual action significantly enhances the epidermal permeability barrier, offering anti-inflammatory and soothing effects, improving hydration, and mitigating markers of irritation, redness, and sensitivity.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
OLEAMIDE SERINOL is registered in the FDA Global Substance Registration System (GSRS) with CAS number 72809-08-6. However, there is currently no specific Cosmetic Ingredient Review (CIR) Expert Panel safety assessment explicitly for OLEOYL OLEAMIDE SERINOL. A broader CIR review on 'alkoxylated fatty amides' concluded they are safe in cosmetics when non-irritating, though it is unconfirmed if this ingredient is covered under that assessment.
Your Skin
Skin Compatibility
Our Assessment
Verdict
OLEOYL OLEAMIDE SERINOL presents a promising biomimetic mechanism for enhancing skin barrier function, providing hydration, and delivering soothing benefits across all skin types; however, comprehensive specific clinical data and safety assessments are currently not available.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources