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OCTAHYDRO-TETRAMETHYL-METHANOAZULENONE.

Questionable CAS 14727-47-0 / PERFUMING

OCTAHYDRO-TETRAMETHYL-METHANOAZULENONE, also known as OTNE, functions primarily as a fragrance component to enhance a product's scent or perfume the skin. It also serves as a general skin conditioning agent, though detailed mechanisms for active skin benefits beyond its aromatic properties are not extensively documented.

Summary

masking perfuming skin conditioning

Science

Mechanism of Action

This ingredient primarily operates by imparting fragrance to formulations and skin, effectively acting as a perfuming and masking agent. While it contributes to maintaining the skin's overall condition, its specific mode of action for delivering active dermatological benefits, distinct from its fragrance role, remains largely unspecified in current research.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The chemical, a colorless to pale-yellow liquid, exhibits stability when stored in sealed amber glass vials at room temperature under a desiccant, showing no degradation over study durations. Formulations containing 12.5% OTNE in 95% ethanol have demonstrated stability for at least 42 days at ambient temperatures and for a minimum of 3 hours under simulated animal room conditions.

Safety

Safety Profile

CIR Status
Under review
Max tested
4.5%
Sensitization risk Moderate

Tetramethyl Acetyloctahydronaphthalenes is currently under assessment, listed on the Cosmetic Ingredient Review (CIR) 2026 Priorities. The Scientific Committee on Consumer Safety (SCCS) recommends its labelling as an EU Fragrance Allergen, citing positive reactions in a small percentage of patients (0.2% to 1.7%) in dermatological clinics, leading to its classification as a regulated allergen in Europe. In contrast, a 13-week repeat dose toxicity study in 2014 by the US National Toxicology Program (NTP), with FDA input, found no adverse effects. The US EPA has also initiated a risk evaluation for OTNE. The International Fragrance Association (IFRA) has provided safe use levels for OTNE in consumer products since August 2009, with the highest 95th percentile concentration in fine fragrances reported at 4.5%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Given its primary function as a fragrance agent and classification as a regulated allergen with medium irritancy, its inclusion in precision skincare formulations is questionable for those prioritizing minimal potential irritants.

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