Science
Mechanism of Action
O-Cresol functions as an antimicrobial agent by inhibiting the proliferation of microorganisms on the skin's surface. Structurally similar to phenol, it shares its disinfectant properties, primarily through the denaturation of proteins. Its inherent irritant nature can manifest as a burning sensation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
O-Cresol is prone to oxidation and degradation upon exposure to air and light, typically manifesting as darkening. It demonstrates violent reactivity with strong oxidants. Its aqueous solution is weakly acidic, characterized by a pKa of 10.316.
Conflicts
- strong oxidants
Safety
Safety Profile
The CIR Expert Panel deems o-Cresol safe for cosmetic use at concentrations not exceeding 0.5%. This limit is established to prevent the occurrence of chemical leukoderma, a form of skin whitening. Formulators should be aware that cresols can enhance the dermal penetration of other active ingredients. While regulated, o-Cresol is corrosive at elevated concentrations and even at lower cosmetic levels, it has been associated with significant dermal irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
O-Cresol, despite its antimicrobial properties, is not recommended for precision skincare formulations due to its high irritancy, potential for dermal penetration enhancement, and strict concentration limits.
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