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Moumoujus

O-ANISALDEHYDE.

Optional CAS 135-02-4 / PERFUMING

O-Anisaldehyde is an aromatic aldehyde primarily valued as a perfuming and flavoring agent. While its main application is in enhancing sensory profiles, it also demonstrates promising *in vitro* antioxidant and antimicrobial activities that warrant further investigation for skincare applications.

Summary

Antioxidant Antimicrobial Perfuming Agent

Science

Mechanism of Action

This compound exhibits antioxidant capabilities by condensing with L-tryptophan. *In vitro* studies indicate antibacterial action against Salmonella enterica (MIC of 2.5 mg/mL) and antifungal effects against Candida species, achieved through the inhibition of plasma membrane H+ ATPase, which leads to intracellular acidification and subsequent cell death.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted
Red flag below
2%

Despite exhibiting *in vitro* antioxidant and antimicrobial properties, O-Anisaldehyde lacks human clinical studies to substantiate its efficacy for direct skin improvement. Its primary role in cosmetics is as a perfuming agent. Therefore, positioning it as a key active ingredient for precision skincare without robust clinical data could constitute 'dusting', especially when exceeding recommended fragrance concentrate levels of 2.00%.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

To maintain product integrity, O-Anisaldehyde should be stored in cool, dry conditions, protected from light. It is sensitive to air exposure, necessitating airtight packaging.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

O-Anisaldehyde is classified with hazard statements including H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with European data also noting skin and eye irritation (R 36/38). However, human experience with a 4% solution showed no irritation or sensitization. Its No Expected Sensitization Induction Level (NESIL) is 3500 μg/cm2. Based on a read-across analog (p-methoxybenzaldehyde), it is not expected to be genotoxic or photoirritating. The FDA status for food additives indicates compliance with 21 CFR 172.515, though it is no longer listed as one of seven synthetic flavoring substances.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Primarily utilized as a perfuming agent, O-Anisaldehyde exhibits *in vitro* antioxidant and antimicrobial properties, but its direct efficacy for skin improvement lacks human clinical validation and it carries irritancy warnings despite positive human experience at 4%.

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