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Moumoujus

O-AMINOPHENOL SULFATE.

Avoid CAS 67845-79-8 / HAIR DYEING

O-AMINOPHENOL SULFATE is primarily utilized as an oxidative precursor in hair dyeing processes, where it reacts with oxidizing agents to generate colored compounds. There is no available information indicating any specific mechanism of action that provides beneficial effects for skin.

Summary

Science

Mechanism of Action

This compound acts as a precursor in oxidative reactions, specifically facilitating hair coloration by forming dye compounds when combined with an oxidizing agent like hydrogen peroxide. However, there is no established mechanism of action on the skin for beneficial dermatological outcomes.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 7.5
0 7 14

Stability

The parent compound, o-aminophenol, typically forms crystals that can readily become gray upon exposure to light. While stable under certain conditions, it may exhibit sensitivity to air or light.

Conflicts

  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Reviewed
Max tested
2%
Sensitization risk High

The Scientific Committee on Consumer Safety (SCCS) has classified o-aminophenol, including its sulfate salt, as a mutagen in category 3. The SCCS also noted data deficiencies regarding the purity, homogeneity, and stability of o-aminophenol and its formulations. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed the parent compound in 1988, but EWG highlights 'Risk assessment method deficiencies and data gaps' from this assessment. A related compound, p-aminophenol sulfate, carries GHS hazard statements indicating 'Suspected of causing genetic defects'. The maximum established concentration for its use in hair dye products is 2%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a potential mutagen, a high irritancy potential, and the complete absence of any established beneficial mechanism for skin, O-AMINOPHENOL SULFATE should be avoided in precision skincare formulations.

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