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Moumoujus

NOSTOC ENDOPHYTUM.

Valuable / SKIN CONDITIONING

Nostoc Endophytum, a cyanobacterium, is rich in polysaccharides, offering robust moisture absorption and protection against environmental stressors like UV radiation and dehydration. Research on related Nostoc species indicates potential for wound healing, anti-inflammatory effects, and antioxidant benefits in skincare.

Summary

Hydrator Antioxidant Anti-inflammatory Skin Protectant Collagen Booster Soothing Wound Healing

Science

Mechanism of Action

Nostoc species primarily function through their polysaccharide content, which significantly enhances skin hydration and fortifies its natural defenses against environmental aggressors. Specific extracts demonstrate anti-inflammatory action by downregulating inflammatory mediators such as IL-6 and β-hexosaminidase, and support skin repair through increased collagen I synthesis, alongside broad antioxidant activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 NCPE, at concentrations between 0.0625-10 mg/ml, exhibited no cytotoxicity in EpiSkin™ human epidermis cells and NIH-3T3 cells after 24 hours. It effectively inhibited IL-6 and β-hexosaminidase while promoting collagen I secretion, suggesting significant wound-healing and anti-allergic potential for cosmetic applications.
  2. 02 An extract containing 0.44 mg/L Zn demonstrated substantial antioxidant activity, achieving 81.22% inhibition in a DPPH assay. The study also noted anticancer activity against various cell lines (A549, Hela, HCT 116, MCF-7) with cell viability as low as 25.57% at 500 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 8 – 12
0 7 14

Stability

An antioxidant-active extract from Nostoc linckia showed remarkable stability across a wide pH range, with observed increases in antioxidant activity specifically between pH 8 and 12.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety assessments (CIR, SCCS, FDA) for Nostoc Endophytum or general Nostoc extracts in skincare are not available. In vitro cytotoxicity and heavy metal assays for Nostoc commune polysaccharide-rich extract indicated safety. While a compound from Nostoc sp. (nostophycin) showed low toxicity against bacteria and fungi, and weak cytotoxicity in specific immune cells at 10 µg/mL, caution is advised due to a report of a Nostoc sp. extract inducing oxidative stress in plant roots, highlighting the need for careful human application assessment.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Nostoc Endophytum holds valuable potential for skincare, based on in vitro research on related Nostoc species demonstrating significant hydrating, antioxidant, anti-inflammatory, and collagen-boosting properties, though specific human clinical data for this exact species is pending.

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