Science
Mechanism of Action
This peptide activates Fibroblast Growth Factors (FGF) and inhibits Insulin Growth Factor (IGF) receptors, both implicated in premature aging. It enhances cell metabolism, DNA repair, and antioxidant enzyme production to protect skin from oxidative stress.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 In-vivo study on 30 volunteers with 1% Clodessine showed 52% wrinkle reduction, 106% elasticity improvement, and 16% pore reduction after 6 weeks.
Transparency
Dusting Analysis
Peptides are generally not commonly 'dusted' due to their cost, specific mechanisms, and formulation challenges like aggregation at high concentrations.
The Formula
Formulation
Stability
NONAPEPTIDE-4 is sensitive to heat and extreme pH. High concentrations can lead to peptide interactions, aggregation, and loss of activity.
Conflicts
- Extreme pH
- Heat
- High concentrations (risk of aggregation)
Safety
Safety Profile
The CIR Expert Panel has not reviewed NONAPEPTIDE-4. Manufacturer safety tests for Clodessine (sh-Nonapeptide-4) have been conducted up to a 1% concentration.
Your Skin
Skin Compatibility
Our Assessment
Verdict
NONAPEPTIDE-4 is a promising anti-aging peptide with strong clinical data from manufacturer studies showing significant improvements in wrinkles, elasticity, and pore size at 1% concentration.
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References
Sources