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Moumoujus

NONANAL.

Questionable CAS 124-19-6 / PERFUMING

Nonanal is a saturated fatty aldehyde and a natural metabolite, valued in cosmetics for its distinct aromatic profile and proposed skin-conditioning benefits. While deemed safe under strict concentration limits up to 1%, its formulation requires careful consideration due to documented potential for contact sensitization and irritation.

Summary

Fragrance Skin Conditioning

Science

Mechanism of Action

As a saturated fatty aldehyde, Nonanal is believed to contribute to skin conditioning, although the precise dermatological pathways and efficacy of these properties are not extensively detailed in current research. Its primary use in formulations is for its pleasant scent.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical studies primarily assess Nonanal's safety and tolerability rather than its direct efficacy for skin conditioning. It has been noted as non-irritating to human skin at 1%.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
1%
Red flag below
1%

Nonanal's CIR-recommended maximum concentration of 1% is a critical safety threshold. Exceeding this, as shown by rabbit studies at 25% and neat material, leads to significant irritation, sensitization risk, and potentially corrosive effects, thus constituting a 'red flag' for consumer safety.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Stable under recommended storage conditions, typically incorporating alpha-Tocopherol (0-0.1%) as a stabilizer. It requires storage in a tightly closed container in a dry, well-ventilated, nitrogen-filled environment to prevent leakage and maintain integrity.

Conflicts

  • Decomposes when heated, emitting acrid smoke and irritating fumes.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%%
Sensitization risk Moderate

Nonanal was found not irritating to human skin at 1% and not sensitizing in some tests at up to 2%. However, a review and case study identified it as a contact allergen, and it was predicted to be positive for skin sensitization in a direct peptide reactivity assay. It is classified with R38 ('Irritating to skin') in European information. No concerns for genotoxicity have been raised by major regulatory bodies.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Nonanal, while offering potential skin conditioning and scent at concentrations up to 1%, presents a moderate risk of sensitization and irritation for sensitive individuals, making its overall benefit questionable given these safety considerations.

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