Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

NICOTINYL TARTRATE.

Questionable CAS 6164-87-0 / SKIN CONDITIONING

Nicotinyl Tartrate, a derivative of Vitamin B3 (niacin), is primarily recognized for its vasodilatory properties, enhancing blood flow to the skin. While it functions as a skin conditioning agent, its use requires careful consideration due to a notable potential for cutaneous flushing and limited clinical efficacy data in cosmetic applications.

Summary

Vasodilator Skin conditioning agent

Science

Mechanism of Action

As a niacin derivative, Nicotinyl Tartrate acts primarily as a vasodilator, promoting increased blood flow by relaxing vascular smooth muscles. This effect is mediated through the release of prostaglandins, particularly prostacyclin (PGI2), and nitric oxide. Beyond its circulatory impact, it contributes to lipid modulation and inhibits free fatty acid mobilization, while also functioning as a skin conditioning agent in topical formulations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 4
0 7 14

Stability

A 1% aqueous solution of Nicotinyl Tartrate maintains stability across a pH range of 3.0 to 4.0 and is reported to be stable under conditions of heat, acidity, and alkalinity. For raw material storage, it is crucial to protect it from heat, direct light, and moisture to prevent degradation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Registered as a Drug/Therapeutic Agent with the FDA (UNII 5G605ZIE90), Nicotinyl Tartrate is known to induce a distinct cutaneous flushing, characterized by warmth and redness, particularly on the face and neck. Its use warrants caution for individuals with a history of peptic ulcers, liver disease, or gout, and should be avoided by those with known niacin allergies. Comprehensive safety data regarding its use in pregnant or breastfeeding individuals is not established.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While demonstrating vasodilatory effects, Nicotinyl Tartrate carries a significant risk of cutaneous flushing and lacks sufficient clinical efficacy data for general cosmetic use, making its inclusion questionable for broad precision skincare applications.

Related

Similar Ingredients

Finding similar ingredients…