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NICOTINOYL S-ALLYLCYSTEINE.

Insufficient Data / BLEACHING

NICOTINOYL S-ALLYLCYSTEINE is a novel derivative of S-Allylcysteine, a compound recognized for its potent antioxidant and anti-inflammatory attributes, primarily found in aged garlic extract. While extensive research exists for its precursor, specific cosmetic applications and efficacy for this particular derivative require further investigation.

Summary

Antioxidant Anti-inflammatory

Science

Mechanism of Action

The foundational component, S-Allylcysteine, demonstrates significant antioxidant activity by effectively scavenging free radicals and restoring critical enzymatic defenses, including glutathione peroxidase, glutathione reductase, and superoxide dismutase. This action helps to diminish lipid peroxidation, DNA fragmentation, protein oxidation, and endoplasmic reticulum stress. Additionally, it exhibits anti-inflammatory effects through the reduction of pro-inflammatory cytokines (e.g., IL-6, IL-1β, IL-1, TNF-α) and suppression of inflammatory pathways such as cyclooxygenase-2 and nuclear factor kappa B. These mechanisms suggest NICOTINOYL S-ALLYLCYSTEINE could offer protective and soothing benefits to the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

S-allyl-L-cysteine is generally considered a highly stable compound, exhibiting resistance to variations in pH, temperature, and aqueous environments. However, observations of reduced S-Allylcysteine content during storage in black garlic suggest a potential susceptibility to oxidation, which may necessitate careful consideration for NICOTINOYL S-ALLYLCYSTEINE formulations over time.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

NICOTINOYL S-ALLYLCYSTEINE has not been reviewed by the Cosmetic Ingredient Review (CIR) or SCCS. Its related compound, S-Allylcysteine, is recognized by the FDA as a food additive but this designation does not apply to cosmetic use. Acute and subacute toxicity studies of S-Allylcysteine in mice and rats indicated very minor toxicity (LD50 >54.7 mM/kg orally; >20 mM/kg intraperitoneally). However, PubChem lists S-Allylcysteine as a primary hazard: Irritant, a factor that warrants caution despite the lack of specific irritation data for NICOTINOYL S-ALLYLCYSTEINE itself.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Due to the absence of specific clinical studies, safety assessments, and application-specific data for NICOTINOYL S-ALLYLCYSTEINE in skincare, its inclusion is currently rated as 'insufficient-data' for a confident recommendation, despite promising mechanistic insights from its precursor, S-Allylcysteine.

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